Evidence map›Paper›PMID 34702857›Full record

Trial reportScientific reports2021

Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity.

Saana M Korkki, Goran Papenberg, Nina Karalija, Douglas D Garrett, Katrine Riklund, Martin Lövdén, Ulman Lindenberger, Lars Nyberg, Lars Bäckman

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Saana M KorkkiAging Research Center, Karolinska Institute and Stockholm University, Stockholm, Sweden. saana.korkki@ki.se.
Goran PapenbergAging Research Center, Karolinska Institute and Stockholm University, Stockholm, Sweden.
Nina KaralijaDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden.
Douglas D GarrettCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Katrine RiklundDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden.
Martin LövdénDepartment of Psychology, University of Gothenburg, Gothenburg, Sweden.
Ulman LindenbergerCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Lars NybergDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden.
Lars BäckmanAging Research Center, Karolinska Institute and Stockholm University, Stockholm, Sweden.
Umeå University · SEKarolinska Institutet · SEMax Planck Institute for Biology of Ageing · DEMax Planck Institute for Human Development · DEStockholm University · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Within-person, moment-to-moment, variability in behavior increases with advancing adult age, potentially reflecting the influence of reduced structural and neurochemical brain integrity, especially that of the dopaminergic system. We examined the role of dopamine D2 receptor (D2DR) availability, grey-, and white-matter integrity, for between-person differences in cognitive variability in a large sample of healthy older adults (n = 181; 64-68 years) from the Cognition, Brain, and Aging (COBRA) study. Intra-individual variability (IIV) in cognition was measured as across-trial variability in participants' response times for tasks assessing perceptual speed and working memory, as well as for a control task of motor speed. Across the whole sample, no associations of D2DR availability, or grey- and white-matter integrity, to IIV were observed. However, within-person variability in cognition was increased in two subgroups of individuals displaying low mean-level cognitive performance, one of which was characterized by low subcortical and cortical D2DR availability. In this latter group, fronto-striatal D2DR availability correlated negatively with within-person variability in cognition. This finding suggests that the influence of D2DR availability on cognitive variability may be more easily disclosed among individuals with low dopamine-system integrity, highlighting the benefits of large-scale studies for delineating heterogeneity in brain-behavior associations in older age.

Indexed as

AgingCognitionMemory, Short-TermAgedCorpus StriatumDopamineGray MatterHumansMiddle AgedReceptors, Dopamine D2White MatterDopamineDRD2 protein, humanReceptors, Dopamine D2

Identifiers

PMID34702857
PMCPMC8548594
OpenAlexW3209111543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.