Evidence map›Paper›PMID 34702745›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Global and Regional Damages in Retinal Ganglion Cell Axon Bundles Monitored Non-Invasively by Visible-Light Optical Coherence Tomography Fibergraphy.

Marta Grannonico, David A Miller, Mingna Liu, Pedro Norat, Christopher D Deppmann, Peter A Netland, Hao F Zhang, Xiaorong Liu

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marta GrannonicoDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
David A MillerDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208.
Mingna LiuDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Pedro NoratDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Christopher D DeppmannDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904.
Peter A NetlandDepartment of Ophthalmology, University of Virginia, Charlottesville, Virginia 22904.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208 hfzhang@northwestern.edu xl8n@virginia.edu.
Xiaorong LiuDepartment of Biology, University of Virginia, Charlottesville, Virginia 22904 hfzhang@northwestern.edu xl8n@virginia.edu.ORCID 0000-0002-7655-6342
University of Virginia · USNorthwestern University · US

Funding

ER Stress and Diabetic RetinopathyR01EY019949 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, SARAH X · 2010 to 2023
$5.5M
Visual Signal Transformation in the Retinocollicular PathwayR01EY026286 · NEI · UNIVERSITY OF VIRGINIA · PI Jianhua Cang · 2016 to 2026
$4.4M
Visible-light optical coherence tomography for clinical glaucoma managementR44EY026466 · NEI · OPTICENT, INC. · PI KURANOV, ROMAN · 2018 to 2023
$2.7M
Investigating oxygen metabolism in diabetic retinopathyR01EY026078 · NEI · NORTHWESTERN UNIVERSITY · PI SHEIBANI, NADER, ZHANG, HAO F · 2016 to 2020
$2.3M
Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detectionR01EY029121 · NEI · NORTHWESTERN UNIVERSITY · PI LIU, XIAORONG, ZHANG, HAO F · 2018 to 2021
$2.0M
Mechanisms underlying the formation of the cornea and ocular surface epitheliumR01EY028304 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KUME, TSUTOMU · 2018 to 2021
$1.6M
NEI NIH HHS R01 EY019949NEI NIH HHS R01 EY026078NEI NIH HHS R01 EY026286NEI NIH HHS R01 EY028304NEI NIH HHS R01 EY029121NEI NIH HHS R44 EY026466
6 · The paper itself

Abstract

Retinal ganglion cells (RGCs) exhibit compartmentalized organization, receiving synaptic inputs through their dendrites and transmitting visual information from the retina to the brain through the optic nerve. Little is known about the structure of RGC axon bundles extending from individual RGC somas to the optic nerve head (ONH) and how they respond to disease insults. We recently introduced visible-light optical coherence tomography fibergraphy (vis-OCTF), a technique for directly visualizing and analyzing mouse RGC axon bundles

Indexed as

AnimalsAxonsFemaleMaleMiceMice, Inbred C57BLNeuroimagingRetinal Ganglion CellsTomography, Optical Coherenceaxon bundlesin vivo imagingoptic neuropathyretinal ganglion cellvisible light optical coherence tomographyvis-OCT fibergram

Identifiers

PMID34702745
PMCPMC8660041
OpenAlexW3209827839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.