Evidence map›Paper›PMID 34702738›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Increased in vitro neutralizing activity of SARS-CoV-2 IgA1 dimers compared to monomers and IgG.

Lin Sun, Somanath Kallolimath, Roman Palt, Karin Stiasny, Patrick Mayrhofer, Daniel Maresch, Lukas Eidenberger, Herta Steinkellner

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 63 citations in OpenAlex.

  1. Plant-Based Systems for Producing Therapeutic Proteins: Current Status and Future Prospects.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. AsymmetricJournal of the American Chemical Society · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Recombinant neutralizing secretory IgA antibodies for preventing mucosal acquisition and transmission of SARS-CoV-2.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lin SunDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.ORCID 0000-0002-4538-5632
Somanath KallolimathDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.ORCID 0000-0001-5364-5919
Roman PaltDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Karin StiasnyCenter for Virology, Medical University of Vienna, 1090 Vienna, Austria.
Patrick MayrhoferDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.ORCID 0000-0003-4763-5911
Daniel MareschCore Facility Mass Spectrometry, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
Lukas EidenbergerDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.ORCID 0000-0002-9491-1416
Herta SteinkellnerDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria; herta.steinkellner@boku.ac.at.
BOKU University · ATMedical University of Vienna · AT

Funding

Austrian Science Fund FWF I 3721Austrian Science Fund FWF W 1224
6 · The paper itself

Abstract

Here, we expressed two neutralizing monoclonal antibodies (Abs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; H4 and B38) in three formats: IgG1, IgA1 monomers (m), and IgA1 dimers (d) in glycoengineered

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, NeutralizingChlorocebus aethiopsCOVID-19Enzyme-Linked Immunosorbent AssayHumansImmunoglobulin AImmunoglobulin GNeutralization TestsSARS-CoV-2Spike Glycoprotein, CoronavirusVero CellsAntibodies, MonoclonalAntibodies, NeutralizingImmunoglobulin AImmunoglobulin GSpike Glycoprotein, CoronavirusIgAmonoclonal antibodiesplant expressionSARS-CoV-2

Identifiers

PMID34702738
PMCPMC8612245
OpenAlexW3210351433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.