Evidence map›Paper›PMID 34702734›Full record

ArticleGenome research2022

Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing.

Samantha L Sholes, Kayarash Karimian, Ariel Gershman, Thomas J Kelly, Winston Timp, Carol W Greider

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 67 citations in OpenAlex.

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  18. A mechanism for telomere-specific telomere length regulation.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Samantha L SholesDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.ORCID 0000-0002-1158-4633
Kayarash KarimianDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.ORCID 0000-0002-5750-5240
Ariel GershmanDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.ORCID 0000-0001-8899-8781
Thomas J KellyProgram in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Winston TimpDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.ORCID 0000-0003-2083-6027
Carol W GreiderDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.ORCID 0000-0002-5494-8126
Johns Hopkins University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI Camila dos Santos · 1985 to 2026
$116.8M
BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Telomeres and Telomerase in CancerR35CA209974 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI GREIDER, CAROL W · 2017 to 2023
$6.3M
Integrative genomic and epigenomic analysis of cancer using long read sequencingU01CA253481 · NCI · JOHNS HOPKINS UNIVERSITY · PI SCHATZ, MICHAEL · 2021 to 2023
$1.1M
NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA209974NCI NIH HHS U01 CA253481NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

We developed a method to tag telomeres and measure telomere length by nanopore sequencing in the yeast

Indexed as

Nanopore SequencingSaccharomyces cerevisiae ProteinsTelomeraseIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesRepressor ProteinsSaccharomyces cerevisiaeTelomereTelomere-Binding ProteinsIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesRepressor ProteinsRIF1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTEL1 protein, S cerevisiaeTelomeraseTelomere-Binding Proteins

Identifiers

PMID34702734
PMCPMC8997346
OpenAlexW3208330807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.