Trial reportBMC medicine2021
Comparison of submucosal and subserosal approaches toward optimized indocyanine green tracer-guided laparoscopic lymphadenectomy for patients with gastric cancer (FUGES-019): a randomized controlled trial.
Trial report in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04219332 (Comparison of Submucosal and Subserosal Approaches Toward Optimized Indocyanine Green Tracer-Guided Laparoscopic Lymphadenectomy for Patients With Gastric Cancer), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Submucosal and Subserosal Approaches Toward Optimized Indocyanine Green Tracer-Guided Laparoscopic Lymphadenectomy for Patients With Gastric Cancer: The FUGES-019 Randomized Clinical Trial
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Evaluating Variations in Indocyanine Green Administration and Its Impact on Nodal Yield in Oesophagogastric Cancer Surgery.Annals of surgical oncology · 2025Pooled it
- The use of indocyanine green and near-infrared fluorescence in the detection of metastatic lymph nodes during oesophageal and gastric cancer resection: a systematic review and meta-analysis.Surgical endoscopy · 2025Pooled it
- Safety and efficacy of indocyanine green near-infrared fluorescent imaging-guided lymph nodes dissection during radical gastrectomy for gastric cancer: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Safety and efficacy of indocyanine green-guided laparoscopic lymphadenectomy for locally advanced gastric cancer: The CLASS-11 clinical trials.Cell reports. Medicine · 2025Trial
- Comparison of a submucosal and subserosal approach in ICG-guided laparoscopic lymphadenectomy in gastric cancer patients: long-term outcomes of a phase 3 randomized clinical trial.International journal of surgery (London, England) · 2025Trial
- Predicting ICG fluorescence uptake in laparoscopic lymphoma biopsy: the role of a 20 mm node size cut-off.Updates in surgery · 2026Article
- Guiding role of indocyanine green fluorescence lymphography compared to standard techniques in lymphadenectomy for gastric cancer during minimally invasive surgery: a systematic review and meta-analysis.Updates in surgery · 2026Review
- CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.Nature communications · 2026Article
- Expert consensus on multidisciplinary management of laparoscopic-endoscopic cooperative surgery combined with sentinel lymph node navigation surgery for early gastric cancer (2026 edition).Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Indocyanine green fluorescence imaging in gastric cancer: Clinical efficacy, technical innovations, and future perspectives.World journal of gastrointestinal surgery · 2025Review
- Fluorescence Guided Surgery in Gastric Cancer: What Do We Have and What Can We Do?Annals of gastroenterological surgery · 2025Review
- Intraoperative visualization of lymphatic flow along the ileocolic artery using ICG fluorescence imaging and its implications for right-sided colon cancer surgery.Surgical endoscopy · 2025Article
- The role of ICG NIRL fluorescence imaging in the surgical treatment of digestive system tumors (Review).Molecular medicine reports · 2025Review
- Beneficial impact of indocyanine green fluorescence imaging on lymphadenectomy in laparoscopic total gastrectomy for advanced upper gastric cancer.Frontiers in oncology · 2025Article
- Current clinical trials on gastric cancer surgery in China.World journal of gastrointestinal oncology · 2024Review
- Applicability of indocyanine green fluorescence tracing with subserosal dye injection in laparoscopic lymph node dissection for gastric cancer: a preliminary study.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Article
- Fluorescence-guided laparoscopic lymph node biopsy for lymphoma: the FLABILY study.Updates in surgery · 2024Article
- Current status and future trends of real-time imaging in gastric cancer surgery: A literature review.Heliyon · 2024Review
- Survival prognostic analysis of laparoscopic D2 radical resection for locally advanced gastric cancer: A multicenter cohort study.World journal of gastrointestinal surgery · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApplication of indocyanine green (ICG) fluorescence imaging is effective in guiding laparoscopic radical lymphadenectomy for gastric cancer. However, the optimal approach for indocyanine green injection is controversial. Therefore, the objective of this study was aimed to compare the efficacy and ICG injection between the preoperative submucosal and intraoperative subserosal approaches for lymph node (LN) tracing during laparoscopic gastrectomy.
methodThis randomized controlled trial (ClinicalTrials.gov, NCT04219332) included 266 patients with potentially resectable gastric cancer (cT1-T4a, N0/+, M0) enrolled from a tertiary teaching center between December 2019 and October 2020. The primary endpoint was total number of retrieved LNs.
resultsIn total, 259 patients (n = 130 and n = 129 in the submucosal and subserosal groups, respectively) were included in the per-protocol analysis. There are no significant differences in total number of retrieved LNs between the two groups (49.8 vs. 49.2, P = 0.713). The rate of LN noncompliance in the submucosal group was comparable to that in the subserosal group (32.3% vs. 33.3%, P = 0.860). No significant difference was found between the submucosal and subserosal groups in terms of the incidence (17.7% vs. 16.3%; P = 0.762) or severity of postoperative complications. The mean fluorescence cost in the submucosal group was higher than that in the subserosal group ($335.3 vs. $182.4; P < 0.001). The overall treatment satisfaction score was lower in the submucosal group than in the subserosal group (70.5 vs. 76.1%, P = 0.048).
conclusionICG administered by subserosal injection was comparable to that administered by submucosal injection for lymph node tracing in gastric cancer. However, the former approach imposed a lower economic and mental burden on patients undergoing laparoscopic D2 lymphadenectomy.
trial registrationClinicalTrials.gov, NCT04219332 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.