Evidence map›Paper›PMID 34702255›Full record

ArticleMalaria journal2021

Baseline malaria prevalence and care-seeking behaviours in rural Madagascar prior to a trial to expand malaria community case management to all ages.

Dean Sayre, Laura C Steinhardt, Judickaelle Irinantenaina, Catherine Dentinger, Tsinjo Fehizoro Rasoanaivo, Laurent Kapesa, Jocelyn Razafindrakoto, Agathe Legrand, Nicole Prada, Julie Gutman and 7 more

Open access · goldAbstract read
In one paragraph

Article in Malaria journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Dean SayreEpidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA, USA. omp2@cdc.gov.ORCID http://orcid.org/0000-0003-3138-2649
Laura C SteinhardtMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, CDC Atlanta, 1600 Clifton Rd, Atlanta, GA, USA.
Judickaelle IrinantenainaInstitut Pasteur de Madagascar , BP 1274 Ambatofotsikely, 101, Antananarivo, Madagascar.
Catherine DentingerMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, CDC Atlanta, 1600 Clifton Rd, Atlanta, GA, USA.
Tsinjo Fehizoro RasoanaivoInstitut Pasteur de Madagascar , BP 1274 Ambatofotsikely, 101, Antananarivo, Madagascar.
Laurent KapesaU.S. President's Malaria Initiative, USAID, Lot 207A, Point Liberty, Andranoro, Antehiroka, 105, Antananarivo, Madagascar.
Jocelyn RazafindrakotoU.S. President's Malaria Initiative, USAID, Lot 207A, Point Liberty, Andranoro, Antehiroka, 105, Antananarivo, Madagascar.
Agathe LegrandInstitut Pasteur de Madagascar , BP 1274 Ambatofotsikely, 101, Antananarivo, Madagascar.
Nicole PradaInstitut Pasteur de Madagascar , BP 1274 Ambatofotsikely, 101, Antananarivo, Madagascar.
Julie GutmanMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, CDC Atlanta, 1600 Clifton Rd, Atlanta, GA, USA.
Lauren LewisU.S. President's Malaria Initiative, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA, USA.
Reziky Tiandraza MangahasimbolaInstitut Pasteur de Madagascar , BP 1274 Ambatofotsikely, 101, Antananarivo, Madagascar.
Mauricette AndriamananjaraNational Malaria Control Programme, Ministry of Health, Antananarivo, Madagascar.
Aimée Vololoniala RavaoarinosyNational Malaria Control Programme, Ministry of Health, Antananarivo, Madagascar.
Nicolas RalemaryMinistry of Public Health, Farafangana District Office, Farafangana, Madagascar.
Andres GarchitorenaInstitut Pasteur de Madagascar , BP 1274 Ambatofotsikely, 101, Antananarivo, Madagascar.
Aina HarimananaInstitut Pasteur de Madagascar , BP 1274 Ambatofotsikely, 101, Antananarivo, Madagascar.
Institut Pasteur de Madagascar · MGU.S. President's Malaria Initiative · USCenter for Global Health · USCenters for Disease Control and Prevention · USCentre National de la Recherche Scientifique · FR

Funding

U.S. President's Malaria Initiative Cooperative Agreement no. 72068719CA00001
6 · The paper itself

Abstract

backgroundIntegrated community case management of malaria, pneumonia, and diarrhoea can reduce mortality in children under five years (CU5) in resource-poor countries. There is growing interest in expanding malaria community case management (mCCM) to older individuals, but limited empirical evidence exists to guide this expansion. As part of a two-year cluster-randomized trial of mCCM expansion to all ages in southeastern Madagascar, a cross-sectional survey was conducted to assess baseline malaria prevalence and healthcare-seeking behaviours.

methodsTwo enumeration areas (EAs) were randomly chosen from each catchment area of the 30 health facilities (HFs) in Farafangana district designated for the mCCM age expansion trial; 28 households were randomly selected from each EA for the survey. All household members were asked about recent illness and care-seeking, and malaria prevalence was assessed by rapid diagnostic test (RDT) among children < 15 years of age. Weighted population estimates and Rao-Scott chi-squared tests were used to examine illness, care-seeking, malaria case management, and malaria prevalence patterns.

resultsIllness in the two weeks prior to the survey was reported by 459 (6.7%) of 8050 respondents in 334 of 1458 households surveyed. Most individuals noting illness (375/459; 82.3%) reported fever. Of those reporting fever, 28.7% (112/375) sought care; this did not vary by participant age (p = 0.66). Most participants seeking care for fever visited public HFs (48/112, 46.8%), or community healthcare volunteers (CHVs) (40/112, 31.0%). Of those presenting with fever at HFs or to CHVs, 87.0% and 71.0%, respectively, reported being tested for malaria. RDT positivity among 3,316 tested children < 15 years was 25.4% (CI: 21.5-29.4%) and increased with age: 16.9% in CU5 versus 31.8% in 5-14-year-olds (p < 0.0001). Among RDT-positive individuals, 28.4% of CU5 and 18.5% of 5-14-year-olds reported fever in the two weeks prior to survey (p = 0.044).

conclusionsThe higher prevalence of malaria among older individuals coupled with high rates of malaria testing for those who sought care at CHVs suggest that expanding mCCM to older individuals may substantially increase the number of infected individuals with improved access to care, which could have additional favorable effects on malaria transmission.

Indexed as

AdolescentCase ManagementChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantMadagascarMalariaMalePatient Acceptance of Health CarePrevalenceRural Population

Identifiers

PMID34702255
PMCPMC8549293
OpenAlexW3209113634

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.