ArticleBMC complementary medicine and therapies2021
Immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium.
Article in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A prospective clinical study on the effectiveness ofJournal of traditional and complementary medicine · 2026Article
- Bioactive Properties of Selected EuropeanInternational journal of molecular sciences · 2025Article
- The Chemical Profiling and Immunological Activity of Polysaccharides from the Rhizome ofMolecules (Basel, Switzerland) · 2025Article
- Modulating effects ofFrontiers in microbiology · 2025Article
- Effects of spent substrate of oyster mushroom (Frontiers in microbiology · 2024Article
- Article
- Evaluation of the Effects ofJournal of microbiology and biotechnology · 2023Article
- Immunostimulatory Effect of Postbiotics Prepared fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Systematic evaluation of the anti-tumor effect of Phellinus linteus polysaccharide in thyroid carcinoma in vitro.Molecular biology reports · 2022Article
- Immune-Enhancing Effect of Submerged Culture ofInternational journal of molecular sciences · 2022Article
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8 authors.
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Abstract
backgroundThe present study extensively aimed to evaluate the underlying mechanism of the immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium (PLM).
methodsTo assess whether PLM influences the production of markers related to inflammation, Lipopolysaccharide (LPS)-stimulated RAW264.7 cells were treated with PLM (50, 100, 200, and 500 μg/mL). Splenocyte, thymus, peritoneal exudate cells (PEC), and peripheral blood mononuclear cells (PBMC) were isolated from the Balb/c mice treated with Korean red ginseng or PLM once a day for 5 weeks. Moreover, all mice except normal mice were stimulated with 10% proteose peptone (PP) treated 3 days before the sacrifice and 2% starch treated 2 days before the sacrifice. Subsequently, the cytotropic substance was evaluated by using flow cytometry analysis and ELISA assay.
resultsPLM200 treatment significantly suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and inhibited the release of proinflammatory cytokines such as interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α dose-dependently in the LPS-stimulated RAW264.7 cells. PLM200 supplementation showed a significant increase in IL-2, IL-12, and interferon (IFN)-γ production and upregulated the ratio of IFN-γ (T-helper type 1, Th1) to IL-4 (T-helper type 2, Th2) in splenocytes. After PLM200 treatment, the significant elevation of CD4
conclusionsTaken together, these results showed an immunomodulatory effect of PLM about an elevated INF-γ/IL4 ratio, as an index of Th1/Th2, as well as the anti-inflammatory effect in the LPS-stimulated RAW264.7 cells. Therefore, our findings demonstrate that PLM possesses immunostimulatory and anti-inflammatory effects.
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