Evidence map›Paper›PMID 34702219›Full record

ArticleBMC nephrology2021

The effect of digoxin on renal function in patients with heart failure.

Parin Shah, Pierpaolo Pellicori, Ian Hanning, Jufen Zhang, Andrew L Clark, Sunil Bhandari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Consensus document on palliative care in cardiorenal patients.Frontiers in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Parin ShahDepartment of Cardiology, Hull York Medical School, Hull and East Yorkshire Medical Research and Teaching Centre, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK. parinshah194@yahoo.co.uk.
Pierpaolo PellicoriDepartment of Cardiology, Hull York Medical School, Hull and East Yorkshire Medical Research and Teaching Centre, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK.
Ian HanningBiochemistry, Pathology department, Hull & East Yorkshire Hospitals NHS Trust, Hull, UK.
Jufen ZhangClinical Trials Unit, Postgraduate Medical Institute, Faculty of Medical Science, Anglia Ruskin University, Bishop Hall Lane, Chelmsford, Essex, CM1 1SQ, UK.
Andrew L Clark *Department of Cardiology, Hull York Medical School, Hull and East Yorkshire Medical Research and Teaching Centre, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK.
Sunil Bhandari *Department of Renal Medicine, Hull and East Yorkshire Hospitals NHS Trust and Hull York Medical School, Heslington, UK.
Castle Hill Hospital · GBHull and East Yorkshire Hospitals NHS Trust · GBAnglia Ruskin University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDigoxin is used in patients with chronic heart failure (CHF) who remain symptomatic despite optimal medical treatment. Impaired renal function is commonly associated with CHF. We investigated the relation between digoxin use and change in renal function over time in patients with CHF.

methodsOne thousand two hundred forty-one patients with symptoms and signs of CHF (average age 72 years (64% male), and median NTproBNP 1426 ng/l (interquartile range 632-2897) were divided into four groups: never on digoxin (N = 394); digoxin throughout (N = 449); started digoxin at some point after baseline (N = 367); and stopped digoxin at some point after baseline (N = 31). The rate of change of estimated glomerular filtration rate (eGFR) was calculated using linear regression.

resultsPatients on digoxin throughout had a significantly greater rate of decline in eGFR per year than patients not on digoxin throughout (mean (± standard deviation); - 5 (14) ml/min/1.73m

conclusionThe rate of decline in renal function is greater in patients with CHF who are taking digoxin.

Indexed as

AgedAged, 80 and overCardiotonic AgentsDigoxinFemaleGlomerular Filtration RateHeart FailureHumansKidneyMaleMiddle AgedRetrospective StudiesTime FactorsCardiotonic AgentsDigoxinDigoxinEstimated glomerular filtration rateHeart failureRenal function

Identifiers

PMID34702219
PMCPMC8549227
OpenAlexW3128632269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.