ArticleBMC neurology2021
Triglyceride glucose index influences platelet reactivity in acute ischemic stroke patients.
Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Pooled it
- The impact of triglyceride-glucose index on ischemic stroke: a systematic review and meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Inflammation mediates the association between the triglyceride-glucose index and non-target lesions progression after PCI: a cohort study.Lipids in health and disease · 2026Article
- Prediabetes and stroke risk in U.S. adults: a machine learning-based analysis with causal mediation insights.Diabetology & metabolic syndrome · 2026Article
- Unveiling a J-shaped association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction: a retrospective cohort study of 1,065 patients.Frontiers in cardiovascular medicine · 2026Article
- Diabetes mediates the association between uric acid to high-density lipoprotein cholesterol ratio and abdominal aortic calcification: a cross-sectional study.Scientific reports · 2025Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
- Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study.BMC neurology · 2025Article
- Triglyceride-glucose index: an independent risk factor for all-cause mortality in critically ill aneurysmal subarachnoid hemorrhage patients- a retrospective analysis of the MIMIC-IV database.Neurosurgical review · 2025Article
- Potential Predictive Value of Platelet Distribution Width for Functional Outcome After Ischemic Stroke.Molecular neurobiology · 2025Article
- Sex-specific associations between the triglyceride-glucose index and new-onset hypertension in a hospital employee cohort: evidence from longitudinal annual health examinations.Frontiers in endocrinology · 2025Article
- Analyzing the correlation between acute ischemic stroke and triglyceride-glucose index based on ordered logistic regression.Frontiers in neurology · 2025Article
- Unveiling the dual threat: combined elevated triglyceride-glucose index and intracranial arterial stenosis burden for enhanced stroke risk stratification.Frontiers in neurology · 2025Article
- Predictive value of triglyceride glucose index in acute kidney injury in patients with severe traumatic brain injury.Scientific reports · 2024Article
- Triglyceride-glucose index: a novel evaluation tool for all-cause mortality in critically ill hemorrhagic stroke patients-a retrospective analysis of the MIMIC-IV database.Cardiovascular diabetology · 2024Article
- Association between triglyceride-glucose index and all-cause mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database.Cardiovascular diabetology · 2023Article
- Waist Circumference Is an Essential Factor in Predicting Insulin Resistance and Early Detection of Metabolic Syndrome in Adults.Nutrients · 2023Article
- Obesity- and lipid-related indices as a predictor of type 2 diabetes in a national cohort study.Frontiers in endocrinology · 2023Article
- Association of novel lipid indicators with the risk of stroke among participants in Central China: a population-based prospective study.Frontiers in endocrinology · 2023Article
- A Novel Metabolic Score for Insulin Resistance and Symptomatic Intracranial Hemorrhage in Ischemic Stroke Patients After Endovascular Thrombectomy.Neuropsychiatric disease and treatment · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimInsulin resistance was reported to increase the risk of ischemic stroke, which can be assessed by the triglyceride glucose (TyG) index. However, it remains unclear whether the TyG index influences the platelet reactivity during the treatment of ischemic patients.
methodsIschemic stroke patients receiving dual antiplatelet therapy (DAPT) within 48 h onset were consecutively included. The TyG index was calculated as ln (fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2). The top quartile of TyG index was defined as insulin resistance. The platelet reactivity was assessed by thromboelastography. The platelet inhibition rate induced by arachidonic acid (AA) or adenosine diphosphate (ADP) was used to confirm the high residual on-treatment platelet reactivity (HRPR) to aspirin or clopidogrel, respectively. The association between TyG index and platelet reactivity was assessed by Kruskal-Wallis test. The independent risk factors of HRPR were determined by multivariate logistic regression analysis.
resultsA total of 1002 patients were included and divided into 4 groups by quartiles of the TyG index (< 2.02; 2.02-2.27; 2.27-2.52; ≥2.52). The findings demonstrated that the maximum intensity of the clot increased, but the AA-induced platelet inhibition rate decreased, depending on the TyG index quartiles. No significant difference was found in the ADP-induced platelet inhibition rate among groups. The prevalence of aspirin HRPR increased depending on the TyG index quartile. Unlike the non-insulin resistance group, the insulin resistance group was independently associated with aspirin HRPR (OR = 1.689, 95% CI 1.14 to 2.51, P = 0.009).
conclusionsIn acute ischemic stroke patients taking DAPT, the elevation of the TyG index is associated with enhanced platelet reactivity and higher prevalence of aspirin HRPR. Insulin resistance assessed by the TyG index could be an independent risk factor for aspirin HRPR.
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