Evidence map›Paper›PMID 34702216›Full record

ReviewBMC pregnancy and childbirth2021

Successful pregnancy and term delivery after treatment of unicornuate uterus with non-communicating rudimentary horn pregnancy with local methotrexate injection followed by laparoscopic resection: a case report and literature review.

Makiko Ueda, Kuniaki Ota, Toshifumi Takahashi, Satoshi Suzuki, Daisuke Suzuki, Hyo Kyozuka, Masatoshi Jimbo, Shu Soeda, Takafumi Watanabe, Keiya Fujimori

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Makiko Ueda *Department of Obstetrics and Gynecology, Fukushima medical University, Fukushima, 960-1295, Japan.
Kuniaki Ota *Fukushima Medical Center for Children and Women, Fukushima medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Toshifumi TakahashiFukushima Medical Center for Children and Women, Fukushima medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan. totakaha@fmu.ac.jp.ORCID http://orcid.org/0000-0003-0955-4248
Satoshi SuzukiDepartment of Obstetrics and Gynecology, Fukushima medical University, Fukushima, 960-1295, Japan.
Daisuke SuzukiFukushima Medical Center for Children and Women, Fukushima medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Hyo KyozukaDepartment of Obstetrics and Gynecology, Fukushima medical University, Fukushima, 960-1295, Japan.
Masatoshi JimboFukushima Medical Center for Children and Women, Fukushima medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Shu SoedaDepartment of Obstetrics and Gynecology, Fukushima medical University, Fukushima, 960-1295, Japan.
Takafumi WatanabeDepartment of Obstetrics and Gynecology, Fukushima medical University, Fukushima, 960-1295, Japan.
Keiya FujimoriDepartment of Obstetrics and Gynecology, Fukushima medical University, Fukushima, 960-1295, Japan.
Fukushima Medical University · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregnancy in a rudimentary horn is an extremely rare type of ectopic pregnancy. A rudimentary uterine horn pregnancy is associated with a risk of spontaneous rupture and bleeding during surgery due to the increased uterine blood flow. Recent advances in imaging modalities have enabled laparoscopic surgery to be performed in cases without rupture in the early stages of pregnancy. However, there are few reports of successful pregnancies and deliveries after treatment of rudimentary horn pregnancies. We report the successful management of a case of non-communicating rudimentary horn pregnancy by local injection of methotrexate followed by complete laparoscopic excision along with a review of the literature. CASE PRESENTATION: The patient was a 29-year-old Japanese woman, gravida 2, nullipara. She was diagnosed with a left unicornuate uterus with a right non-communicating rudimentary horn on hysterosalpingography and magnetic resonance imaging. A gestational sac with a heartbeat was observed in the right rudimentary uterine horn at 6 weeks of gestation. A diagnosis of ectopic pregnancy in a non-communicating rudimentary horn was made. Color Doppler detected multiple blood flow signals around the gestational sac, which were clearly increased compared to the left unicornuate uterus. Her serum human chorionic gonadotropin level was 104,619 mIU/ml. A 100 mg methotrexate injection into the gestational sac was administered, and laparoscopic surgery was performed on day 48 after the methotrexate treatment. The right rudimentary horn and fallopian tube were successfully excised with minimal bleeding. A spontaneous normal pregnancy was established 6 months after the surgery. The pregnancy was uneventful, and a baby girl was born by elective cesarean section at 38w0d.

conclusionCombined local methotrexate injection and laparoscopic surgery are safe treatment options for patients with a unicornuate uterus with a non-communicating rudimentary horn pregnancy.

Indexed as

AdultFemaleHumansJapanLaparoscopyMethotrexatePregnancyPregnancy, CornualPregnancy OutcomeTerm BirthUrogenital AbnormalitiesUterusMethotrexateCase reportEctopic pregnancyLaparoscopyMethotrexateRudimentary horn

Identifiers

PMID34702216
PMCPMC8547051
OpenAlexW3207984917

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.