Evidence map›Paper›PMID 34702132›Full record

ArticleBioengineered2021

Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer.

Yonghui Liu, Chengwen Zhao, Jing Sun, Guihua Wang, Shaoqing Ju, Chen Qian, Xudong Wang

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  14. The Potential Role of Small Nucleolar RNAs in Cancers - An Evidence Map.International journal of general medicine · 2022
    Review
  15. Article
  16. miR-3150b-3p Promotes Vascular Smooth Muscle Cell Injury by Targeting ARL5B.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yonghui LiuDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.ORCID 0000-0002-0875-8604
Chengwen ZhaoDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Jing SunDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Guihua WangDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Shaoqing JuDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Chen QianDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Xudong WangDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.ORCID 0000-0002-3522-3971
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the second most incident cancer and third leading cause of cancer-related mortality worldwide. Small nucleolar RNAs (snoRNAs) are small non-coding RNAs located in the nucleoli of cells, and play key roles in multiple cancers. However, the role of serum snoRNAs in CRC remains unknown. We analyzed the expression of the snoRNA SNORD1C in the serum of patients with CRC using quantitative real-time polymerase chain reaction (qRT-PCR) (n = 122). The receiver operating characteristic (ROC) curves were estimated, and the area under the ROC curve (AUC) was calculated. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) analysis of co-expressed genes was performed using the database for annotation, visualization, and integrated discovery (DAVID), and visualized by R language. The results showed that the expression of SNORD1C in patients with CRC (n = 122) was significantly higher than that in normal individuals (n = 50) and patients with benign colorectal disease (n = 33) (

Indexed as

Biomarkers, TumorCase-Control StudiesColorectal NeoplasmsFemaleHumansMaleMiddle AgedPrognosisRNA, Small NucleolarRNA, UntranslatedROC CurveBiomarkers, TumorRNA, Small NucleolarRNA, UntranslatedSNORD45A noncoding RNA, humanbiomarkercolorectal cancerdiagnosisSmall nucleolar RNAsSNORD1C

Identifiers

PMID34702132
PMCPMC8806983
OpenAlexW3211191823

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.