Evidence map›Paper›PMID 34700350›Full record

ArticleAmerican journal on intellectual and developmental disabilities2021

The FMR1 Premutation Phenotype and Mother-Youth Synchrony in Fragile X Syndrome.

Carly Moser, Laura Mattie, Leonard Abbeduto, Jessica Klusek

Open access · greenAbstract read
In one paragraph

Article in American journal on intellectual and developmental disabilities, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. The impact of individual factors on linguistic alignment of autistic boys and their mothers.Autism : the international journal of research and practice · 2026
    Article
  2. Prelinguistic Communication Complexity of Children With Neurogenetic Syndromes.Journal of speech, language, and hearing research : JSLHR · 2025
    Article
  3. Social Communication Delay in an Unbiased Sample of Preschoolers With theJournal of speech, language, and hearing research : JSLHR · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carly MoserCarly Moser, University of South Carolina.
Laura MattieLaura Mattie, University of Illinois, Champaign.
Leonard AbbedutoLeonard Abbeduto, University of California.
Jessica KlusekDavis; and Jessica Klusek, University of South Carolina.
University of South Carolina · USUniversity of Illinois Urbana-Champaign · US

Funding

Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JUDY A. VAN DE WATER · 2020 to 2026
$9.7M
LINGUISTIC COMMUNICATION AND MENTAL RETARDATIONR01HD024356 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ABBEDUTO, LEONARD J. · 1987 to 2022
$9.0M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Defining the Language Phenotype of the FMR1 PremutationR21DC017804 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KLUSEK, JESSICA · 2019 to 2021
$684k
Aging Language Trajectories in Premutation Carrier MothersR03HD098291 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KLUSEK, JESSICA · 2019 to 2020
$149k
Profiles and Predictors of Pragmatic Language Impairments in the FMR1 PremutationF32DC013934 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KLUSEK, JESSICA · 2014 to 2016
$145k
NICHD NIH HHS P50 HD103526NICHD NIH HHS P50 HD103573NICHD NIH HHS R01 HD024356NICHD NIH HHS R03 HD098291NICHD NIH HHS U54 HD079125NIDCD NIH HHS F32 DC013934NIDCD NIH HHS R21 DC017804NIMH NIH HHS L40 MH108014
6 · The paper itself

Abstract

A subset of mothers who carry the FMR1 premutation may express a unique phenotype. The relationship between the FMR1 phenotype and mother-child interaction in families with fragile X-associated disorders has not been well characterized, despite the importance of high-quality mother-child interaction for child development. This study examined the association between the FMR1 phenotype and the quality of interactions between mothers and their adolescent/young adult sons with fragile X syndrome. Mother-youth synchrony was coded from a dyadic interaction. Maternal anxiety and depression symptoms, executive function deficits, and pragmatic language difficulties were evaluated. Results indicated that pragmatic language was associated with mother-youth synchrony. These findings highlight the importance of family-centered intervention practices for families with fragile X-associated disorders.

Indexed as

Fragile X SyndromeMothersAdolescentExecutive FunctionFemaleFragile X Messenger Ribonucleoprotein 1HumansPhenotypeFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1fragile X carrierFXSmother-child interactionpragmatic language

Identifiers

PMID34700350
PMCPMC8555425
OpenAlexW3210761157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.