Evidence map›Paper›PMID 34700291›Full record

ReviewJournal of infection and public health2021

Opportunistic mycoses in COVID-19 patients/survivors: Epidemic inside a pandemic.

Haripriya Kuchi Bhotla, Balamuralikrishnan Balasubramanian, Arun Meyyazhagan, Karthika Pushparaj, Murugesh Easwaran, Manikantan Pappusamy, Asirvatham Alwin Robert, Vijaya Anand Arumugam, Valentina Tsibizova, Abdullah Msaad Alfalih and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of infection and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Global, Regional, and National Burden of Pulmonary Fungal Infections 1990-2021.American journal of respiratory and critical care medicine · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Association of COVID with Mycosis in General.Infectious disorders drug targets · 2024
    Review
  7. SevereJournal of intensive medicine · 2023
    Review
  8. Article
  9. Review
  10. Diagnostics (Basel, Switzerland) · 2022
    Article
  11. Pathogens (Basel, Switzerland) · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 6 countries.

Haripriya Kuchi BhotlaDepartment of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029 Karnataka, India.
Balamuralikrishnan BalasubramanianDepartment of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea.
Arun MeyyazhaganDepartment of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029 Karnataka, India; Department of Obstetrics and Gynecology, Centre for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy. Electronic address: arun47biotech@gmail.com.
Karthika PushparajDepartment of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, 641 043, Tamil Nadu, India.
Murugesh EaswaranComputational Biology Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu 641 046, India.
Manikantan PappusamyDepartment of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029 Karnataka, India.
Asirvatham Alwin RobertDepartment of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Vijaya Anand ArumugamMedical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India.
Valentina TsibizovaInstitute of Perinatology and Pediatrics, Almazov National Medical Research Centre, Saint-Petersburg, Russian Federation.
Abdullah Msaad AlfalihDepartment of Botany and Microbiology, College of Science, King Saud University, P.O Box 24552, 11495, Riyadh, Saudi Arabia.
Reem M AljowaieDepartment of Botany and Microbiology, College of Science, King Saud University, P.O Box 24552, 11495, Riyadh, Saudi Arabia.
Muthupandian SaravananDepartment of Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health Science, Mekelle University, Mekelle, 1871, Ethiopia; Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Dental College, 600077, Chennai, Tamil Nadu, India. Electronic address: bioinfosaran@gmail.com.
Gian Carlo Di RenzoDepartment of Obstetrics and Gynecology, Centre for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy. Electronic address: giancarlo.direnzo@unipg.it.
Bharathiar University · INChrist University · INKing Saud University · SAUniversity of Perugia · ITAvinashilingam University · INFederal Almazov North-West Medical Research Centre · RUMekelle University · ETRiyadh Armed Forces Hospital · SASejong University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Being considered minor vexations, fungal infections hinder the life of about 15% of the world population superficially, with rare threats to life in case of invasive sepsis. A significant rise in the intrusive mycoses due to machiavellian fungal species is observed over the years due to increased pathology and fatality in people battling life-threatening diseases. Individuals undergoing therapy with immune suppressive drugs plus recovering from viral infections have shown to develop fungal sepsis as secondary infections while recovering or after. Currently, the whole world is fighting against the fright of Coronavirus disease (COVID-19), and corticosteroids being the primitive therapeutic to combat the COVID-19 inflammation, leads to an immune-compromised state, thereby allowing the not so harmful fungi to violate the immune barrier and flourish in the host. A wide range of fungal co-infection is observed in the survivors and patients of COVID-19. Fungal species of Candida, Aspergillus and Mucorales, are burdening the lives of COVID-19 patients/survivors in the form of Yellow/Green, White and Black fungus. This is the first article of its kind to assemble note on fungal infections seen in the current human health scenario till date and provides a strong message to the clinicians, researchers and physicians around the world "non-pathological fungus should not be dismissed as contaminants, they can quell immunocompromised hosts".

Indexed as

COVID-19MycosesHumansPandemicsSARS-CoV-2SurvivorsCorticosteroidsCOVID-19ImmunosuppressedIntrusive fungusSepsis

Identifiers

PMID34700291
PMCPMC8518133
OpenAlexW3205131431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.