Evidence map›Paper›PMID 34700145›Full record

ArticleDrug and alcohol dependence2021

Treatment for alcohol use disorder among persons with and without HIV in a clinical care setting in the United States.

Thibaut Davy-Mendez, Varada Sarovar, Tory Levine-Hall, Alexandra N Lea, Stacy A Sterling, Felicia W Chi, Vanessa A Palzes, Kendall J Bryant, Constance M Weisner, Michael J Silverberg and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thibaut Davy-MendezDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, 401 Parnassus Ave, San Francisco, CA 94143, USA; Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA. Electronic address: tdavy@med.unc.edu.
Varada SarovarDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Tory Levine-HallDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Alexandra N LeaDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Stacy A SterlingDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Felicia W ChiDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Vanessa A PalzesDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Kendall J BryantNational Institute on Alcohol Abuse and Alcoholism HIV/AIDS Program, Bethesda, MD 20892-7003, USA.
Constance M WeisnerDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Michael J SilverbergDivision of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.
Derek D SatreDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, 401 Parnassus Ave, San Francisco, CA 94143, USA; Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA.

Funding

Substance Use Disorders Treatment/Services Research Training ProgramT32DA007250 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre, Janice Y Tsoh · 1991 to 2026
$7.4M
2/3 COMpAAAS Tripartite: ART-CC, KP, and VAU01AA026230 · NIAAA · KAISER FOUNDATION RESEARCH INSTITUTE · PI SATRE, DEREK D, SILVERBERG, MICHAEL J · 2017 to 2021
$3.0M
Mentoring alcohol use intervention research in HIV health care settingsK24AA025703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre · 2018 to 2026
$1.8M
Population-based Screening and Brief Intervention in Primary Care: Health and Drinking Outcomes, Cost and UtilizationR01AA025902 · NIAAA · KAISER FOUNDATION RESEARCH INSTITUTE · PI STERLING, STACY ANN · 2017 to 2020
$1.6M
NIAAA NIH HHS K24 AA025703NIAAA NIH HHS R01 AA025902NIAAA NIH HHS U01 AA026230NIDA NIH HHS T32 DA007250
6 · The paper itself

Abstract

backgroundAlcohol use disorders (AUD) can lead to poor health outcomes. Little is known about AUD treatment among persons with HIV (PWH). In an integrated health system in Northern California, 2014-2017, we compared AUD treatment rates between PWH with AUD and persons without HIV (PWoH) with AUD.

methodsUsing Poisson regression with GEE, we estimated prevalence ratios (PRs) comparing the annual probability of receiving AUD treatment (behavioral intervention or dispensed medication), adjusted for sociodemographics, psychiatric comorbidities, insurance type, and calendar year. Among PWH, we examined independent AUD treatment predictors using PRs adjusted for calendar year only.

resultsPWH with AUD (N = 633; 93% men, median age 49) were likelier than PWoH with AUD (N = 7006; 95% men, median age 52) to have depression (38% vs. 21%) and a non-alcohol substance use disorder (SUD, 48% vs. 25%) (both P < 0.01). Annual probabilities of receiving AUD treatment were 45.4% for PWH and 34.4% for PWoH. After adjusting, there was no difference by HIV status (PR 1.02 [95% CI 0.94-1.11]; P = 0.61). Of treated PWH, 59% received only a behavioral intervention, 5% only a medication, and 36% both, vs. 67%, 4%, 30% for treated PWoH, respectively. Irrespective of HIV status, the most common medication was gabapentin. Among PWH, receiving AUD treatment was associated with having depression (PR 1.78 [1.51-2.10]; P < 0.01) and another SUD (PR 2.68 [2.20-3.27]; P < 0.01).

conclusionsPWH with AUD had higher AUD treatment rates than PWoH with AUD in unadjusted but not adjusted analyses, which may be explained by higher psychiatric comorbidity burden among PWH.

Indexed as

AlcoholismHIV InfectionsAlcohol DrinkingComorbidityFemaleHumansMaleMiddle AgedPrevalenceUnited StatesAlcohol use disorderDepressionGabapentinHIVNaltrexonePharmacotherapyPsychotherapyUnhealthy alcohol use

Identifiers

PMID34700145
PMCPMC8671330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.