Evidence map›Paper›PMID 34700024›Full record

ArticleAmerican journal of obstetrics & gynecology MFM2022

Stillbirth and fetal capillary infection by SARS-CoV-2.

Cira di Gioia, Fabrizio Zullo, Roberta Costanza Bruno Vecchio, Cristina Pajno, Giuseppina Perrone, Paola Galoppi, Francesco Pecorini, Daniele Di Mascio, Raffaella Carletti, Carla Prezioso and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of obstetrics & gynecology MFM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes.International journal of environmental research and public health · 2023
    Observational
  5. Article
  6. SARS-CoV-2 can infect human embryos.Scientific reports · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Cira di GioiaThe Departments of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Fabrizio ZulloMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy. Electronic address: f.zullo@hotmail.it.
Roberta Costanza Bruno VecchioMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Cristina PajnoMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Giuseppina PerroneMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Paola GaloppiMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Francesco PecoriniMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Daniele Di MascioMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Raffaella CarlettiTranslational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Carla PreziosoPublic Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy; L'Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Roma, Rome, Italy.
Valeria PietropaoloPublic Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Laura MasuelliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Roberto BeiDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
Costantino CiallellaDepartment of Anatomical, Histological, Forensic Medicine, and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.
Carlo Della RoccaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Antonella GiancottiMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Roberto BrunelliMaternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We presented the case of stillbirth in a paucisymptomatic mother affected by SARS-CoV-2. At gross examination, the placenta showed a diffuse marble appearance and a focal hemorrhagic area. Multiple areas of hemorrhagic or ischemic necrosis with central and peripheral villous infarctions and thrombosis of several maternal and fetal vessels with luminal fibrin and platelet deposition were observed. All lesions seemed to be synchronous. Virus particles were identified within the cytoplasm of endothelial cells using electron microscopy, whereas SARS-CoV-2 RNA was detected in the placental tissue using real-time reverse transcription-polymerase chain reaction. Here, fetal vascular malperfusion was associated with infection; in fact, electron microscopy images showed that marked SARS-CoV-2 endotheliotropism involved the intravillous fetal capillaries. Furthermore, we confirmed that syncytiotrophoblast is the major target cell type for SARS-CoV-2 infection of the placenta. In conclusion, the possible consequences of the action of the placentotropic SARS-CoV-2 included the occurrence of vertical transmission, as reported in the literature, and/or stillbirth: the latter possibility may be triggered by a hampered maternal and/or fetal perfusion of the placenta. The diffuse thrombosis and subsequent ischemia of fetal capillaries induced by COVID-19 cannot be predicted by standard clinical surveillance.

Indexed as

COVID-19StillbirthCapillariesEndothelial CellsFemaleHumansPlacentaPregnancyRNA, ViralSARS-CoV-2RNA, Viral

Identifiers

PMID34700024
PMCPMC8541829
OpenAlexW3210200685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.