Evidence map›Paper›PMID 34699788›Full record

ArticleExperimental neurology2022

Daily acute intermittent hypoxia enhances serotonergic innervation of hypoglossal motor nuclei in rats with and without cervical spinal injury.

Marissa C Ciesla, Yasin B Seven, Latoya L Allen, Kristin N Smith, Elisa J Gonzalez-Rothi, Gordon S Mitchell

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marissa C CieslaBreathing Research and Therapeutics Center, Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Yasin B SevenBreathing Research and Therapeutics Center, Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Latoya L AllenBreathing Research and Therapeutics Center, Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Kristin N SmithBreathing Research and Therapeutics Center, Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Elisa J Gonzalez-RothiBreathing Research and Therapeutics Center, Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Gordon S MitchellBreathing Research and Therapeutics Center, Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address: gsmitche@phhp.ufl.edu.
University of Florida · US

Funding

Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
Functional mapping of peripheral and central circuits for airway protection and breathingOT2OD023854 · OD · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C · 2016 to 2020
$10.8M
Training In Rehabilitation and Neuromuscular PlasticityT32HD043730 · NICHD · UNIVERSITY OF FLORIDA · PI DAVID D FULLER · 2003 to 2026
$5.3M
Respiratory plasticity and spinal cord InjuryR37HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2002 to 2011
$4.2M
Optimizing respiratory plasticity with chronic cervical SCIR01HL147554 · NHLBI · UNIVERSITY OF FLORIDA · PI MITCHELL, GORDON S. · 2019 to 2022
$2.9M
Respiratory Plasticity and Spinal Cord InjuryR01HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2014 to 2017
$1.5M
Nanoparticle-Based Drug Delivery Targeting the Respiratory Neural NetworkR21NS119862 · NINDS · UNIVERSITY OF FLORIDA · PI SEVEN, YASIN B · 2021 to 2021
$424k
NHLBI NIH HHS R01 HL069064NHLBI NIH HHS R01 HL147554NHLBI NIH HHS R37 HL069064NICHD NIH HHS K12 HD055929NICHD NIH HHS T32 HD043730NIH HHS OT2 OD023854NINDS NIH HHS R21 NS119862
6 · The paper itself

Abstract

Intermittent hypoxia elicits protocol-dependent effects on hypoglossal (XII) motor plasticity. Whereas low-dose, acute intermittent hypoxia (AIH) elicits serotonin-dependent plasticity in XII motor neurons, high-dose, chronic intermittent hypoxia (CIH) elicits neuroinflammation that undermines AIH-induced plasticity. Preconditioning with repeated AIH and mild CIH enhance AIH-induced XII motor plasticity. Since intermittent hypoxia pre-conditioning could enhance serotonin-dependent XII motor plasticity by increasing serotonergic innervation density of the XII motor nuclei, we tested the hypothesis that 3 distinct intermittent hypoxia protocols commonly studied to elicit plasticity (AIH) or simulate aspects of sleep apnea (CIH) differentially affect XII serotonergic innervation. Sleep apnea and associated CIH are common in people with cervical spinal injuries and, since repetitive AIH is emerging as a promising therapeutic strategy to improve respiratory and non-respiratory motor function after spinal injury, we also tested the hypotheses that XII serotonergic innervation is increased by repetitive AIH and/or CIH in rats with cervical C2 hemisections (C2Hx). Serotonergic innervation was assessed via immunofluorescence in male Sprague Dawley rats, with and without C2Hx (beginning 8 weeks post-injury) exposed to 28 days of: 1) normoxia; 2) daily AIH (10, 5-min 10.5% O2 episodes per day; 5-min normoxic intervals); 3) mild CIH (5-min 10.5% O2 episodes; 5-min intervals; 8 h/day); and 4) moderate CIH (2-min 10.5% O2 episodes; 2-min intervals; 8 h/day). Daily AIH, but neither CIH protocol, increased the area of serotonergic immunolabeling in the XII motor nuclei in both intact and injured rats. C2Hx per se had no effect on XII serotonergic innervation density. Thus, daily AIH may increases XII serotonergic innervation and function, enhancing the capacity for serotonin-dependent, AIH-induced plasticity in upper airway motor neurons. Such effects may preserve upper airway patency and/or swallowing ability in people with cervical spinal cord injuries and other clinical disorders that compromise breathing and airway defense.

Indexed as

AnimalsCervical VertebraeHypoglossal NerveHypoxiaMaleRatsRats, Sprague-DawleySerotonergic NeuronsSpinal Cord InjuriesCervical hemisectionHypoglossalIntermittent hypoxiaMotor neuronPlasticityRapheSerotoninSpinal cord injury

Identifiers

PMID34699788
PMCPMC8848979
OpenAlexW3208542765

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.