Evidence map›Paper›PMID 34699733›Full record

ArticleOpen biology2021

The role of DDK and Treslin-MTBP in coordinating replication licensing and pre-initiation complex formation.

Ilaria Volpi, Peter J Gillespie, Gaganmeet Singh Chadha, J Julian Blow

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. CDC7 and APC/CNature communications · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ilaria VolpiCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Peter J GillespieCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Gaganmeet Singh ChadhaCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
J Julian BlowCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.ORCID 0000-0002-9524-5849
University of Dundee · GB

Funding

Cancer Research UK 14301Cancer Research UK C303/A14301Wellcome Trust WT096598MA
6 · The paper itself

Abstract

Treslin/Ticrr is required for the initiation of DNA replication and binds to MTBP (Mdm2 Binding Protein). Here, we show that in

Indexed as

AnimalsCarrier ProteinsCell Cycle ProteinsChromatinCyclin-Dependent KinasesDNA ReplicationFemaleGene Expression RegulationMaleProtein MultimerizationProtein Serine-Threonine KinasesS PhaseXenopus laevisXenopus ProteinsCarrier ProteinsCDC7 protein, XenopusCell Cycle ProteinsChromatinCyclin-Dependent KinasesProtein Serine-Threonine KinasesTICRR protein, XenopusXenopus ProteinsDDKMTBPPP1simurosertibTopBP1Treslin

Identifiers

PMID34699733
PMCPMC8548084
OpenAlexW3210817153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.