ArticleMicrobial genomics2021
Differential nasopharyngeal microbiota composition in children according to respiratory health status.
Article in Microbial genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the microbial landscape of the nasopharynx in children: a systematic review of studies using next generation sequencing.Frontiers in microbiomes · 2023Pooled it
- Nasopharyngeal microbiota profiles and lytA-PCR status in adult pneumococcal pneumonia: distinct microbial communities and diagnostic implications.Pneumonia (Nathan Qld.) · 2026Article
- Presence of Dolosigranulum pigrum in the nasopharynx and its relationship with respiratory health status in paediatric population.PloS one · 2026Article
- Parental self-efficacy, health locus of control, and preventive behaviors against respiratory infections in young children: a cross-sectional survey study.Frontiers in public health · 2026Article
- Early development and dynamics of nasopharyngeal microbiota in infants during the COVID-19 pandemic: a 2-year prospective birth cohort study.Respiratory research · 2025Article
- Synergistic inhibition of pneumococcal growth byMicrobiology spectrum · 2025Article
- Characterizing acute respiratory infections in primary care for better management of viral infections.NPJ primary care respiratory medicine · 2025Article
- Pneumococcal nasopharyngeal carriage in children and adults self-confined at home during a COVID-19 national lockdown.PloS one · 2024Article
- The airway microbiota of neonates colonized with asthma-associated pathogenic bacteria.Nature communications · 2023Article
- The impact of respiratory infections and probiotic use on the nasal microbiota of frail residents in long-term care homes.ERJ open research · 2023Article
- Environmental factors related to differences in the microbiota in the upper respiratory tract in young children: Focusing on the impact of early nursery attendance.Frontiers in pediatrics · 2023Article
- Impact of COVID-19 Lockdown on the Nasopharyngeal Microbiota of Children and Adults Self-Confined at Home.Viruses · 2022Article
- Characterization of the Upper Respiratory Bacterial Microbiome in Critically Ill COVID-19 Patients.Biomedicines · 2022Article
- Bacterial microbiomes from mucus and breath of southern resident killer whales (Conservation physiology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute respiratory infections (ARIs) constitute one of the leading causes of antibiotic administration, hospitalization and death among children <5 years old. The upper respiratory tract microbiota has been suggested to explain differential susceptibility to ARIs and modulate ARI severity. The aim of the present study was to investigate the relation of nasopharyngeal microbiota and other microbiological parameters with respiratory health and disease, and to assess nasopharyngeal microbiota diagnostic utility for discriminating between different respiratory health statuses. We conducted a prospective case-control study at Hospital Sant Joan de Deu (Barcelona, Spain) from 2014 to 2018. This study included three groups of children <18 years with gradual decrease of ARI severity: cases with invasive pneumococcal disease (IPD) (representative of lower respiratory tract infections and systemic infections), symptomatic controls with mild viral upper respiratory tract infections (URTI), and healthy/asymptomatic controls according to an approximate case-control ratio 1:2. Nasopharyngeal samples were collected from participants for detection, quantification and serotyping of pneumococcal DNA, viral DNA/RNA detection and 16S rRNA gene sequencing. Microbiological parameters were included on case-control classification models. A total of 140 subjects were recruited (IPD=27, URTI=48, healthy/asymptomatic control=65). Children's nasopharyngeal microbiota composition varied according to respiratory health status and infection severity. The IPD group was characterized by overrepresentation of
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