Evidence map›Paper›PMID 34699170›Full record

ArticleACS chemical biology2021

Synthetic Natural Product Inspired Cyclic Peptides.

Matthew A Hostetler, Chloe Smith, Samantha Nelson, Zachary Budimir, Ramya Modi, Ian Woolsey, Autumn Frerk, Braden Baker, Jessica Gantt, Elizabeth I Parkinson

Abstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Discovery and Development of Cyclic Peptide Proteasome Stimulators.Chembiochem : a European journal of chemical biology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew A HostetlerDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Chloe SmithDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Samantha NelsonDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.
Zachary BudimirDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Ramya ModiDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Ian WoolseyDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Autumn FrerkDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Braden BakerDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Jessica GanttDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Elizabeth I ParkinsonDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-3665-5522

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Mining Cryptic Biosynthetic Gene Clusters for Novel Bioactive Compounds and BiocatalystsR35GM138002 · NIGMS · PURDUE UNIVERSITY · PI Elizabeth Ivy Parkinson · 2020 to 2026
$2.9M
NCI NIH HHS P30 CA023168NIGMS NIH HHS R35 GM138002
6 · The paper itself

Abstract

Natural products are a bountiful source of bioactive molecules. Unfortunately, discovery of novel bioactive natural products is challenging due to cryptic biosynthetic gene clusters, low titers, and arduous purifications. Herein, we describe SNaPP (

Indexed as

Anti-Bacterial AgentsBiological ProductsComputational BiologyCyclizationDrug DiscoveryDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsMultigene FamilyPenicillin-Binding ProteinsPeptides, CyclicSolid-Phase Synthesis TechniquesAnti-Bacterial AgentsBiological ProductsPenicillin-Binding ProteinsPeptides, Cyclic

Identifiers

PMID34699170
PMCPMC8610019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.