Evidence map›Paper›PMID 34699134›Full record

ArticleInternational wound journal2022

Adding collagen to adipose tissue transplant increases engraftment by promoting cell proliferation, neovascularisation and macrophage activity in a rat model.

Chika Suzuki, Takako Komiya, Hana Inoue, Takayuki Yoshimoto, Hajime Matsumura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Advanced Hydrogels in Breast Cancer Therapy.Gels (Basel, Switzerland) · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chika SuzukiDepartment of Plastic and Reconstructive Surgery, Tokyo Medical University, Tokyo, Japan.
Takako KomiyaDepartment of Plastic and Reconstructive Surgery, Tokyo Medical University, Tokyo, Japan.
Hana InoueDepartment of Physiology, Tokyo Medical University, Tokyo, Japan.
Takayuki YoshimotoDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Hajime MatsumuraDepartment of Plastic and Reconstructive Surgery, Tokyo Medical University, Tokyo, Japan.
Tokyo Medical University · JP

Funding

Japan Society for the Promotion of Science 16K11381
6 · The paper itself

Abstract

To clarify the effect of collagen addition to transplanted adipose tissue on angiogenesis, cell proliferation and tissue remodelling process and reveal whether collagen addition contributes to improving transplanted adipose tissue engraftment in rats. Adipose tissue was harvested from the inguinal and injected into the back of the rat, in addition to collagen. Engraftment tissue was harvested, semi-quantitatively evaluated and underwent haematoxylin and eosin or Perilipin staining. Moreover, we evaluated viable adipocyte counts and neovascularisation. Macrophages were evaluated using flow cytometry, and the adiponectin or vascular endothelial growth factor (VEGF) mRNA was detected using real-time polymerase chain reaction. By collagen addition to transplanted adipose tissue, higher engraftment rate semi-quantitatively and a greater number of new blood vessels histologically were identified. Perilipin staining revealed a higher adipocyte number. The total cell, M1 macrophage and M2 macrophage count were higher. There was increased adiponectin mRNA significantly at week 4 compared to that at week 1 after transplantation. Note that the expression levels of VEGF mRNA increased. In rats, adding collagen enhanced cell proliferation, induced M2 macrophages, which are involved in wound healing, and promoted adipocytes and neovascularisation. Therefore, collagen addition to transplanted adipose tissue could increase the engraftment rate of adipose tissue.

Indexed as

AdiponectinVascular Endothelial Growth Factor AAdipose TissueAnimalsCell ProliferationCollagenMacrophagesPerilipinsRatsRNA, MessengerAdiponectinCollagenPerilipinsRNA, MessengerVascular Endothelial Growth Factor Aadipose tissue transplantationcell proliferationcollagen additionM1 macrophageM2 macrophage

Identifiers

PMID34699134
PMCPMC9284645
OpenAlexW3209500408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.