Evidence map›Paper›PMID 34699040›Full record

Trial reportApplied biochemistry and biotechnology2022

Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain.

S Hameed Kadar Ali, K Wasim Ali Raja, N Irfan, Mohammad Habeeb, Y Ismail

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Applied biochemistry and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

S Hameed Kadar AliSchool of Social Sciences, BSA Crescent Institute of Science and Technology, Chennai, 600048, India. kadarali@crescent.education.
K Wasim Ali RajaSri Lakshmi Narayana Institute of Medical Sciences, Puducherry, 605502, India.
N IrfanCrescent School of Pharmacy, BSA Crescent Institute of Science and Technology, Chennai, 600048, India.
Mohammad HabeebCrescent School of Pharmacy, BSA Crescent Institute of Science and Technology, Chennai, 600048, India.
Y IsmailCrescent School of Pharmacy, BSA Crescent Institute of Science and Technology, Chennai, 600048, India.
B.S. Abdur Rahman Crescent Institute of Science & Technology · INNarayana Health · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fundamental aim of this study is to establish the role of antioxidant supplementation in alleviating acute amitriptyline induced oxidative stress. The effect of supplementation was compared on treatment of acute amitriptyline intoxication cases for pain management, with alpha lipoic acid (ALA) alone or with vitamin C, with that of healthy individuals (group I), and those receiving only routine standard treatment (RST) as control (group II). A total of 132 human subjects divided into 5 groups were supplemented with either placebo, RST, RST with vitamin C, RST with ALA, or RST with vitamin C, and ALA. Results of this study revealed that the decrease in the level of oxidative stress and enzyme activity was observed among those supplemented with either alpha lipoic acid alone or along with vitamin C, with a slightly more decrease in the latter group. P value of < 0.001 was considered statistically significant. The percentage of benefit of treatment on supplementation with vitamin C and alpha lipoic acid showed a marked increase in group V cases after supplementation with both in combination. The results provided that the oxidative stress induced by acute amitriptyline poisoning is comparatively decreased by supplementation with antioxidants like alpha lipoic acid and vitamin C, than those only on routine standard treatment.

Indexed as

Dietary SupplementsAcute DiseaseAdultAmitriptylineAntioxidantsAscorbic AcidFemaleHumansMaleOxidative StressPainSubstance-Related DisordersThioctic AcidAmitriptylineAntioxidantsAscorbic AcidThioctic AcidAlpha lipoic acidAmitriptyline abuseFree radicalsOxidative stressVitamin C

Identifiers

PMID34699040
OpenAlexW3198457918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.