ArticleEnvironmental geochemistry and health2022
The association between hemoglobin level and osteoporosis in a Chinese population with environmental lead and cadmium exposure.
Article in Environmental geochemistry and health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Association between anaemia and osteoporosis: a systematic review and meta-analysis.Annals of medicine · 2026Pooled it
- Airborne contaminant exposure and bone development: a systematic review and meta-analysis.Toxicological sciences : an official journal of the Society of Toxicology · 2026Pooled it
- Metallic Contaminants and Osteoporosis: a Review of the Gut-Bone Axis.Biological trace element research · 2026Review
- Association between the Dietary Index for Gut Microbiota and osteoporosis: a cross-sectional study from NHANES among individuals aged ≥ 50 years.Archives of medical science : AMS · 2026Article
- Dietary Iron Supplementation Protects Against Growth Restriction and Metabolic Dysfunction-Associated Steatotic Liver Disease in Perinatal Cadmium-Exposed Mice.FASEB bioAdvances · 2025Article
- Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells.Biological trace element research · 2025Article
- Analysis of the association between mixed exposure to multiple metals and comorbidity of osteopenia or osteoporosis: baseline data from the Chinese Multi-Ethnic Cohort study (CMEC).BMC public health · 2025Article
- Environmental Lead Exposure Predicts Lower Bone Mineral Density in a Large Taiwanese Population-Based Study.International journal of medical sciences · 2025Article
- Environmental Contaminants, Iron Deficiency, and Iron-Deficiency Anemia: A Review of the Literature.Scientifica · 2025Review
- Toxic Metals and Metalloids in Food: Current Status, Health Risks, and Mitigation Strategies.Current environmental health reports · 2024Review
- Association Between Combined Polymetallic Exposure and Osteoporosis.Biological trace element research · 2024Article
- Article
- Special Issue "Geochemistry, Soil Contamination and Human Health. Part 2."Environmental geochemistry and health · 2022Article
- Hemoglobin level and osteoporosis in Chinese elders with type 2 diabetes mellitus.Nutrition & diabetes · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Low hemoglobin (Hb) level or anemia is associated with osteoporosis and bone fracture. Cadmium (Cd) and lead (Pb) exposure are also risk factors of osteoporosis and anemia. However, the role of anemia in Cd/Pb related bone loss remains unclear. The aim of present study was to investigate the association between Hb level and bone loss in a population with environmental lead and cadmium exposure. One hundred and ninety-four women and 108 men with different levels of Cd/Pb exposure were included in our study. The Cd/Pb exposure was determined using graphite-furnace atomic absorption spectrometry. Forearm bone mineral density (BMD) was determined by peripheral dual-energy X-ray absortiometry. Hb concentration was determined using an automatic blood cellcounter. A logistic model was established to predict the risk of osteoporosis. The BMDs of women that had the highest quartile BCd and BPb were markedly lower than that with the lowest quartile (p < 0.05). The BMD and the prevalence of osteoporosis in men with anemia were lower and higher than that with normal Hb (p < 0.05), respectively. In men, age, BPb and anemia were independent risk factors for osteoporosis. The odds ratio (OR) of men with anemia was 11.28 (95%confidence interval (CI):1.94-65.54) and 19.56 (95%CI: 2.98-128.78) compared to those with normal Hb after adjusting for potential cofounders. No such association was found in women. The area under the curve was 0.88 (95%CI: 0.82-0.96) in predicting osteoporosis using the logistic model in men. Linear discriminant analysis also showed that 90.7% of osteoporosis was correctly classified. Our data show that anemia is associated with incident of osteoporosis in men but not in women that environmentally exposed to Pb and Cd.
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