Evidence map›Paper›PMID 34698960›Full record

ArticleCellular and molecular neurobiology2022

Tissue-Specific Gamma-Flicker Light Noninvasively Ameliorates Retinal Aging.

Wang Sheng, Da Lv, Ze-Kai Cui, Yi-Ni Wang, Bin Lin, Shi-Bo Tang, Jian-Su Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Wang ShengAier School of Ophthalmology, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0003-0196-2060
Da LvAier School of Ophthalmology, Central South University, Changsha, Hunan, China.
Ze-Kai CuiAier Eye Institute, Changsha, Hunan, China.
Yi-Ni WangAier Eye Institute, Changsha, Hunan, China.
Bin LinSchool of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Shi-Bo TangAier School of Ophthalmology, Central South University, Changsha, Hunan, China. tangshibo@vip.163.com.
Jian-Su ChenAier School of Ophthalmology, Central South University, Changsha, Hunan, China. chenjiansu2000@163.com.ORCID http://orcid.org/0000-0001-6703-9573
Central South University · CNHong Kong Polytechnic University · HK

Funding

fundamental research funds for central universities of the central south university 2019zzts368national natural science foundation of china 32061160469research grant of key laboratory of regenerative medicine, ministry of education, jinan university ZSYX-M-2019-00010the hong kong polytechnic university joint supervision scheme with the chinese mainland, taiwan and macao universities G-SB1A
6 · The paper itself

Abstract

Aging is a risk factor for multiple retinal degeneration diseases. Entraining brain gamma oscillations with gamma-flicker light (γFL) has been confirmed to coordinate pathological changes in several Alzheimer's disease mouse models and aged mice. However, the direct effect of γFL on retinal aging remains unknown. We assessed retinal senescence-associated beta-galactosidase (β-gal) and autofluorescence in 20-month-old mice and found reduced β-gal-positive cells in the inner retina and diminished lipofuscin accumulation around retinal vessels after 6 days of γFL. In immunofluorescence, γFL was further demonstrated to ameliorate aging-related retinal changes, including a decline in microtubule-associated protein 1 light chain 3 beta expression, an increase in complement C3 activity, and an imbalance between the anti-oxidant factor catalase and pro-oxidant factor carboxymethyl lysine. Moreover, we found that γFL can increase the expression of activating transcription factor 4 (ATF4) in the inner retina, while revealing a decrease of ATF4 expression in the inner retina and positive expression in the outer segment of photoreceptor and RPE layer for aged mice. Western blotting was then used to confirm the immunofluorescence results. After mRNA sequencing (NCBI Sequence Read Archive database: PRJNA748184), we found several main mechanistic clues, including mitochondrial function and chaperone-mediated protein folding. Furthermore, we extended γFL to aged Apoe

Indexed as

Complement C3LipofuscinActivating Transcription Factor 4AnimalsAntioxidantsApolipoproteins Ebeta-GalactosidaseCatalaseLysineMiceMicrotubule-Associated ProteinsReactive Oxygen SpeciesRetinaRNA, MessengerActivating Transcription Factor 4AntioxidantsApolipoproteins Ebeta-GalactosidaseCatalaseComplement C3LipofuscinLysineMicrotubule-Associated ProteinsReactive Oxygen SpeciesRNA, MessengerAgingMitochondrial disordersMolecular chaperonesPhototherapyRetina

Identifiers

PMID34698960
PMCPMC11421622
OpenAlexW3208546429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.