Evidence map›Paper›PMID 34698911›Full record

ReviewMolecular diversity2022

A review on the synthesis of heteroannulated quinolones and their biological activities.

Yaseen A M M Elshaier, Ashraf A Aly, Mohamed Abd El-Aziz, Hazem M Fathy, Alan B Brown, Mohamed Ramadan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular diversity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Molecular Rearrangement of Pyrazino[2,3-International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaseen A M M ElshaierOrganic & Medicinal Chemistry Department, Faculty of Pharmacy, University of Sadat City, Menoufia, 32958, Egypt.
Ashraf A AlyChemistry Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt. ashrafaly63@yahoo.com.ORCID http://orcid.org/0000-0002-0314-3408
Mohamed Abd El-AzizMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, El-Minia, 61519, Egypt.
Hazem M FathyOrganic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524, Egypt.
Alan B BrownChemistry Department, Florida Institute of Technology, Melbourne, FL, 32901, USA.
Mohamed RamadanOrganic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The quinoline scaffold has become an important construction motif for the development of new drugs. The quinolones and their heteroannulated derivatives have high importance due to their diverse spectrum of biological activities as antifungal, anti-inflammatory, anti-diabetes, anti-Alzheimer's disease, antioxidant and diuretic activities. This review summarizes the various new, efficient and convenient synthetic approaches to synthesize diverse quinolone-based scaffolds and their biological activities. We also dealt with the important mechanism, the route and type of reactions of the obtained products. The biological activities of some heteroannulated quinolones were also discussed.

Indexed as

QuinolonesAntifungal AgentsAntifungal AgentsQuinolonesBiological activitiesFuroquinolonesHeteroannulationOxazoloquinolonesPyranoquinolonesPyrroloquinolonesThienoquinolones

Identifiers

PMID34698911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.