ArticleMammalian genome : official journal of the International Mammalian Genome Society2022
Progress towards completing the mutant mouse null resource.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mouse phenome database: curated data repository with interactive multi-population and multi-trait analyses.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Pooled it
- Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines.Development (Cambridge, England) · 2026Article
- lncRNAlyzr: Enrichment Analysis for lncRNA Sets.Journal of molecular biology · 2025Article
- Twenty-first century mouse genetics is again at an inflection point.Lab animal · 2025Review
- Commentary: The International Mouse Phenotyping Consortium: high-throughput in vivo functional annotation of the mammalian genome.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Engineering structural variants to interrogate genome function.Nature genetics · 2024Review
- A graph theoretical approach to experimental prioritization in genome-scale investigations.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Computational strategies for cross-species knowledge transfer and translational biomedicine.ArXiv · 2024Article
- How is Big Data reshaping preclinical aging research?Lab animal · 2023Review
- Essential genes: a cross-species perspective.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- Spontaneous allelic variant in deafness-blindness gene Ush1g resulting in an expanded phenotype.Genes, brain, and behavior · 2023Article
- De novo PAM generation to reach initially inaccessible target sites for base editing.Development (Cambridge, England) · 2023Article
- Genetic and Molecular Quality Control of Genetically Engineered Mice.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Contribution of model organism phenotypes to the computational identification of human disease genes.Disease models & mechanisms · 2022Article
- X-linked palindromic gene families 4930567H17Rik and Mageb5 are dispensable for male mouse fertility.Scientific reports · 2022Article
- Mouse mutagenesis and phenotyping to generate models of development and disease.Current topics in developmental biology · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The generation of a comprehensive catalog of null alleles covering all protein-coding genes is the goal of the International Mouse Phenotyping Consortium. Over the past 20 years, significant progress has been made towards achieving this goal through the combined efforts of many large-scale programs that built an embryonic stem cell resource to generate knockout mice and more recently employed CRISPR/Cas9-based mutagenesis to delete critical regions predicted to result in frameshift mutations, thus, ablating gene function. The IMPC initiative builds on prior and ongoing work by individual research groups creating gene knockouts in the mouse. Here, we analyze the collective efforts focusing on the combined null allele resource resulting from strains developed by the research community and large-scale production programs. Based upon this pooled analysis, we examine the remaining fraction of protein-coding genes focusing on clearly defined mouse-human orthologs as the highest priority for completing the mutant mouse null resource. In summary, we find that there are less than 3400 mouse-human orthologs remaining in the genome without a targeted null allele that can be further prioritized to achieve our overall goal of the complete functional annotation of the protein-coding portion of a mammalian genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.