Evidence map›Paper›PMID 34698820›Full record

ArticleChemical senses2021

Prevalence and correlates of parosmia and phantosmia among smell disorders.

Robert Pellegrino, Joel D Mainland, Christine E Kelly, Jane K Parker, Thomas Hummel

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Chemical senses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06283745 (Randomized Clinical Trial of Intranasal Injection of Platelet-Rich Plasma for Treatment of Parosmia), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06283745 narecruitingnot on this mapstarted 2024, after this paper: background citation

Randomized Clinical Trial of Intranasal Injection of Platelet-Rich Plasma for Treatment of Parosmia

TypeinterventionalSponsorStanford UniversityRan2024 to 2027Enrolled40ConditionsParaosmiaArmsPlatelet-rich Plasma (PRP), Saline
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 65 citations in OpenAlex.

  1. Persistent COVID-19 parosmia and olfactory loss post olfactory training: randomized clinical trial comparing central and peripheral-acting therapeutics.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Trial
  2. Review
  3. Self-Reported Smell and Taste Disorders in the General Population: A Cross-Sectional Survey in Austria, Germany and Switzerland.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  4. Observational
  5. Real-World Outcomes of 3-Month Olfactory Training on Post-COVID-19 Parosmia.ORL; journal for oto-rhino-laryngology and its related specialties · 2025
    Article
  6. Article
  7. Assessment of olfactory recovery after COVID-19: cross-sectional study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  8. Article
  9. Review
  10. Functional connectivity patterns in parosmia.Behavioral and brain functions : BBF · 2023
    Article
  11. Orthonasal and retronasal odor identification in patients with parosmia.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  12. Review
  13. Article
  14. Olfactory Function and Olfactory Disorders.Laryngo- rhino- otologie · 2023
    Article
  15. Article
  16. Olfactory Dysfunction: Etiology, Diagnosis, and Treatment.Deutsches Arzteblatt international · 2023
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Robert PellegrinoMonell Chemical Senses Center, Philadelphia, PA, USA.ORCID 0000-0001-7436-8826
Joel D MainlandMonell Chemical Senses Center, Philadelphia, PA, USA.ORCID 0000-0002-5056-4598
Christine E KellyAbScent, 14 London Road, Andover, Hampshire, UK.ORCID 0000-0002-4476-3208
Jane K ParkerDepartment of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UK.ORCID 0000-0003-4121-5481
Thomas HummelSmell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.ORCID 0000-0001-9713-0183
Monell Chemical Senses Center · USTechnische Universität Dresden · DEUniversity of Reading · GB

Funding

INTERDISCIPLINARY TRAINING IN THE CHEMICAL SENSEST32DC000014 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI PAMELA HELEN DALTON, Joel D Mainland · 1989 to 2026
$6.2M
NIDCD NIH HHS T32 DC000014
6 · The paper itself

Abstract

Among those many individuals who experience a reduced odor sensitivity (hyposmia/anosmia), some individuals also have disorders that lead to odor distortion, such as parosmia (i.e. distorted odor with a known source), or odor phantoms (i.e. odor sensation without an odor source). We surveyed a large population with at least one olfactory disorder (N = 2031) and found that odor distortions were common (46%), with respondents reporting either parosmia (19%), phantosmia (11%), or both (16%). In comparison to respondents with hyposmia or anosmia, respondents with parosmia were more likely to be female, young, and suffering from post-viral olfactory loss (P < 0.001), while respondents with phantosmia were more likely to be middle-aged (P < 0.01) and experiencing symptoms caused by head trauma (P < 0.01). In addition, parosmia, compared to phantosmia or anosmia/hyposmia, was most prevalent 3 months to a year after olfactory symptom onset (P < 0.001), which coincides with the timeline of physiological recovery. Finally, we observed that the frequency and duration of distortions negatively affects the quality of life, with parosmia showing a higher range of severity than phantosmia (P < 0.001). Previous research often grouped these distortions together, but our results show that they have distinct patterns of demographics, medical history, and loss in quality of life.

Indexed as

Olfaction DisordersQuality of LifeFemaleHumansMaleMiddle AgedOdorantsPrevalenceSmellanosmiadistortionimpairmentolfactorysmell

Identifiers

PMID34698820
PMCPMC8633731
OpenAlexW3210036039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.