Evidence map›Paper›PMID 34698639›Full record

ArticleeLife2021

Fusion of tethered membranes can be driven by Sec18/NSF and Sec17/αSNAP without HOPS.

Hongki Song, William T Wickner

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hongki SongDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, United States.ORCID https://orcid.org/0000-0002-3761-5434
William T WicknerDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, United States.ORCID https://orcid.org/0000-0001-8431-0468
Dartmouth College · US

Funding

Mechanisms of Membrane FusionR35GM118037 · NIGMS · DARTMOUTH COLLEGE · PI WILLIAM Tobey WICKNER · 2016 to 2026
$8.6M
NIGMS NIH HHS R35 GM118037
6 · The paper itself

Abstract

Yeast vacuolar membrane fusion has been reconstituted with R, Qa, Qb, and Qc-family SNAREs, Sec17/αSNAP, Sec18/NSF, and the hexameric HOPS complex. HOPS tethers membranes and catalyzes SNARE assembly into RQaQbQc

Indexed as

Membrane FusionAdenosine TriphosphatasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsVesicular Transport ProteinsAdenosine TriphosphatasesSaccharomyces cerevisiae ProteinsSEC17 protein, S cerevisiaeSEC18 protein, S cerevisiaeSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsVesicular Transport Proteinsbiochemistrychemical biologyHOPSmembrane fusionS. cerevisiaeSec17Sec18SNAREsyeast vacuole

Identifiers

PMID34698639
PMCPMC8560088
OpenAlexW3210383292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.