Evidence map›Paper›PMID 34698634›Full record

ArticleeLife2021

Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD.

Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-Ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. N-glycan-dependent protein maturation and quality control in the ER.Nature reviews. Molecular cell biology · 2025
    Review
  3. Article
  4. Article
  5. Turnover of EDEM1, an ERAD-enhancing factor, is mediated by multiple degradation routes.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Article
  6. Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?Current issues in molecular biology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Ginto George *Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0003-4804-9594
Satoshi Ninagawa *Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0002-8005-4716
Hirokazu YagiGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID 0000-0001-9296-0225
Jun-Ichi FurukawaDepartment of Advanced Clinical Glycobiology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.ORCID 0000-0002-7284-2261
Noritaka HashiiDivision of Biological Chemistry and Biologicals, National Institute of Health Sciences, Kawasaki, Japan.ORCID 0000-0003-1363-2050
Akiko Ishii-WatabeDivision of Biological Chemistry and Biologicals, National Institute of Health Sciences, Kawasaki, Japan.
Ying DengDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0003-4657-9284
Kazutoshi MatsushitaDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0002-5666-9630
Tokiro IshikawaDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0003-1718-6764
Yugoviandi P MamahitDepartment of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Japan.ORCID 0000-0002-2974-7795
Yuta MakiDepartment of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Japan.ORCID 0000-0002-5838-302X
Yasuhiro KajiharaDepartment of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Japan.ORCID 0000-0002-6656-2394
Koichi KatoGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID 0000-0001-7187-9612
Tetsuya OkadaDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0002-2513-1301
Kazutoshi MoriDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0001-7378-4019
Kyoto University · JPThe University of Osaka · JPNational Institute of Health Sciences · JPHokkaido University · JPNagoya City University · JPNational Institutes of Natural Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sequential mannose trimming of

Indexed as

alpha-MannosidaseCalcium-Binding ProteinsCell LineEndoplasmic Reticulum-Associated DegradationGlycoproteinsHumansMembrane ProteinsOligosaccharidesalpha-MannosidaseCalcium-Binding ProteinsEDEM1 protein, humanEDEM3 protein, humanGlycoproteinsMembrane ProteinsOligosaccharidesbiochemistrycell biologychemical biologyglycoproteinhumanmannose trimmingprotein degradation

Identifiers

PMID34698634
PMCPMC8570694
OpenAlexW3209531672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.