Evidence map›Paper›PMID 34698613›Full record

ArticleThe journal of spinal cord medicine2023

Indicators of publicly funded prescription opioid use among persons with traumatic spinal cord injury in Ontario, Canada.

Qi Guan, Andrew Calzavara, Lauren Cadel, Mary-Ellen Hogan, Daniel McCormack, Tejal Patel, Aisha K Lofters, Sander L Hitzig, Sara J T Guilcher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of spinal cord medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qi GuanInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Andrew CalzavaraICES, Toronto, Ontario, Canada.
Lauren CadelLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Mary-Ellen HoganLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Daniel McCormackICES, Toronto, Ontario, Canada.
Tejal PatelUniversity of Waterloo School of Pharmacy, Kitchener, Ontario, Canada.
Aisha K LoftersICES, Toronto, Ontario, Canada.ORCID 0000-0002-7322-0894
Sander L HitzigRehabilitation Sciences Institute, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-9139-9250
Sara J T GuilcherInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-9552-9139

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the proportion and identify predictors of community-dwelling individuals with traumatic spinal cord injury (TSCI) who were dispensed ≥1 publicly funded opioid in the year after injury using a retrospective cohort study.

settingOntario, Canada. PARTICIPANTS, INTERVENTIONS, OUTCOME MEASURES: We used administrative data to identify predictors of receiving publicly funded prescription opioids during the year after injury for individuals who were injured between April 2004 and March 2015. Our outcome was modeled using robust Poisson multivariable regression and we reported adjusted relative risks (aRR) with 95% confidence intervals.

resultsIn our retrospective cohort of 934 individuals with TSCI who were eligible for the provincial drug program, 510 (55%) received ≥1 prescription opioid in the year after their injury. Most individuals were male (71%) and the median age was 63 years (interquartile range: 42-72). Being male (aRR 1.15, 95% confidence interval [CI] 1.01-1.31), having chronic obstructive pulmonary disease (aRR 1.25, 95% CI 1.05-1.50), and using prescription opioids before injury (aRR 1.46, 95% CI 1.29-1.66) were significantly associated with receiving opioids in the year after TSCI. Short durations of hospital stay after injury were also identified as being a significant risk factor of outpatient opioid use (aRR = 1.28, 95% CI = 1.08-1.51) when compared to longer hospital stays.

conclusionThis study presented evidence showing that most individuals eligible for Ontario's public drug program who experienced a TSCI used opioids in the year following their injury. Due to the paucity of research on this population and their potential for elevated risks of adverse events, it is important for additional studies to be conducted on opioid use in this population to understand short-term and long-term risks and benefits.

Indexed as

Analgesics, OpioidSpinal Cord InjuriesFemaleHumansMaleMiddle AgedOntarioPrescriptionsRetrospective StudiesAnalgesics, OpioidOpioidsPain managementTraumatic spinal cord injury

Identifiers

PMID34698613
PMCPMC10653736

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.