Evidence map›Paper›PMID 34698356›Full record

ArticleActa dermato-venereologica2021

Quality of Life and Psychopathology in Lichen Planus: A Neglected Disease Burden.

Zeno Fiocco, Sophie Kupf, Leilah Patzak, Till Kämmerer, Teodora Pumnea, Lars E French, Markus Reinholz

Abstract read
In one paragraph

Article in Acta dermato-venereologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Article
  6. Article
  7. Article
  8. Article
  9. [Treatment of oral lichen planus-a review].Dermatologie (Heidelberg, Germany) · 2025
    Review
  10. History, clinical presentation, therapy, and patient reported outcomes of mucosal lichen planus: a cross-sectional study.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Article
  11. Article
  12. Lichen Planus: What is New in Diagnosis and Treatment?American journal of clinical dermatology · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Comprehensive Insight into Lichen Planus Immunopathogenesis.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zeno FioccoDepartment of Dermatology and Allergy, University Hospital, LMU Munich, Frauenlobstr. 9-11, DE-80337 Munich, Germany . Zeno.Fiocco@med.uni-muenchen.de.
Sophie Kupf
Leilah Patzak
Till Kämmerer
Teodora Pumnea
Lars E French
Markus Reinholz

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The disease burden of lichen planus and its impact on patients' quality of life have not been well studied. The aim of this mono-centre cross-sectional study was to investigate these factors. From June to September 2020, an anonymous survey was posted to 253 patients, who were diagnosed with lichen planus in our outpatient clinic from January 2018 to June 2020. Quality of life was evaluated using the Dermatology Life Quality Index (DLQI), the EuroQol 5-dimension 3-level score, and further quality of life indicators. Beck Depression Inventory II was used to evaluate symptoms of depression. A total of 100 patients completed and returned the survey. Lichen planus affected quality of life in 78% of cases. DLQI was higher for multiple localizations (r = 0.454, p < 0.001). Patients with genital lichen planus had a significantly higher DLQI (mean ± standard deviation (SD) 8.68 ± 6.96) than patients who were not affected in the genital area (5.01 ± 5.49; p = 0.009). DLQI was also significantly higher for ungual lichen planus (9.83 ± 7.6; not affected: 5.65 ± 5.84; p-value 0.039), and for cutaneous LP (mean 8.1, SD 6.22; not affected: 5.63 ± 6.12; p-value 0.045). Twenty-nine percent of patients had mild to moderate symptoms of depression, and 6% had severe symptoms of depression. Depression and reduced quality of life are an undetected and relevant burden affecting patients with lichen planus.

Indexed as

Lichen PlanusLichen Planus, OralMental DisordersCost of IllnessCross-Sectional StudiesHumansNeglected DiseasesQuality of Life

Identifiers

PMID34698356
PMCPMC9472096

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.