Evidence map›Paper›PMID 34698341›Full record

ArticleEndocrinology2022

In Vitro Differentiation of Leydig Cells From hiPSCs: A First Step Towards a Cellular Therapy for Hypogonadism?

Xiaowei Gu, Tony DeFalco

Open access · hybridAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. In vitro models of the male reproductive system: applications for developmental and reproductive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiaowei GuDivision of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Tony DeFalcoDivision of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-4133-7040
Cincinnati Children's Hospital Medical Center · US

Funding

Macrophage regulation of the spermatogonial stem cell nicheR35GM119458 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI DEFALCO, TONY J. · 2016 to 2020
$1.9M
Exploring vascular-mesenchymal interactions in the stem cell nicheR01HD094698 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI DEFALCO, TONY J. · 2018 to 2022
$1.6M
NICHD NIH HHS R01 HD094698NIGMS NIH HHS R35 GM119458
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HypogonadismLeydig CellsCell DifferentiationHumansMalehypogonadisminduced pluripotent stem cells (iPSCs)in vitro differentiationLeydig cellreproductive agingtestosterone

Identifiers

PMID34698341
PMCPMC8599747
OpenAlexW3209270249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.