Evidence map›Paper›PMID 34698334›Full record

ArticleAmerican journal of clinical pathology2022

Clinicopathologic and Proteomic Analysis of Amyloidomas Involving the Ocular Surface and Adnexa.

Pouya Jamshidi, Jonathan Levi, Maria Jose Suarez, Roxana Rivera, Nicholas Mahoney, Charles G Eberhart, Avi Rosenberg, Fausto J Rodriguez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of clinical pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Subepithelial Lesions of the Ocular Surface: A Review.Current ophthalmology reports · 2025
    Review
  2. Nasopharyngeal amyloidoma: report of three cases and review of the literature.Journal of cancer research and clinical oncology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Pouya JamshidiDepartment of Pathology and Laboratory Medicine, Northshore University Health System, Evanston, IL, USA.
Jonathan LeviNational Institutes of Health, Bethesda, MD, USA.
Maria Jose SuarezDepartment of Infectious Diseases, Maimonides Medical Center, Brooklyn, NY, USA.
Roxana RiveraCincinnati Eye Institute, Cincinnati and Department of Ophthalmology, University of Cincinnati, Cincinnati, OH, USA.
Nicholas MahoneyDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Charles G EberhartDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Avi RosenbergDepartment of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Fausto J RodriguezDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8662-1219
Johns Hopkins University · USCincinnati Eye Institute · USMaimonides Medical Center · USNational Institutes of Health · USNorthShore University HealthSystem · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

objectivesOcular amyloidoma is a rare disorder characterized by deposition of insoluble proteinaceous fibrils in the extracellular space of the ocular adnexa. This study details the clinicopathologic features and proteomic characteristics of periocular amyloid deposition.

methodsSpecimens (1991-2020) were retrieved and reviewed. All available H&E slides and special stains were reviewed. Proteomic analysis was performed using immunohistochemistry (IHC) for IgG, IgG4, IgA, IgD, IgM, CD20, CD3, CD138, and κ/λ, as well as chromatography-electrospray tandem mass spectrometry on formalin-fixed, paraffin-embedded tissue.

resultsThere were 14 patients (7 men, 7 women). The depositions involved eyelid (n = 3), conjunctiva (n = 8), and orbit (n = 3). All patients were adults with a median age at diagnosis of 56 (range, 39-88) years. The deposits were predominantly λ light chain restricted (n = 6) and mixed light chains (n = 2), and one case was κ predominant. Two of the cases with a mixture of κ and λ light chains had an excess of transthyretin by mass spectrometry. Four of the cases did not have adequate material for proteomic subtyping.

conclusionsAmyloidomas involving ocular adnexa contain a variety of amyloid-related and immunoglobulin-associated peptides. The λ light chain predominates as in other body sites, but mixed patterns and rarely κ light chain restriction may be encountered.

Indexed as

AmyloidosisAdultAmyloidEye DiseasesFemaleHumansImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsImmunohistochemistryMaleProteomicsAmyloidImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsAdnexaAmyloidImmunoglobulinMass spectrometryOcular

Identifiers

PMID34698334
PMCPMC8973273
OpenAlexW3208565530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.