Evidence map›Paper›PMID 34698184›Full record

ReviewJournal of functional biomaterials2021

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery.

Sai H S Boddu, Prakash Bhagav, Pradeep K Karla, Shery Jacob, Mansi D Adatiya, Tejas M Dhameliya, Ketan M Ranch, Amit K Tiwari

Open access · goldAbstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Synthesis of Poly(Amino Acids) Using Ring Opening Polymerization.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  8. Review
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  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Sai H S BodduDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman P.O. Box 346, United Arab Emirates.ORCID 0000-0003-2513-5879
Prakash BhagavAdvanced Drug Delivery Research and Development, Sampann Research and Development, Panacea Biotec Ltd., Ambala, Chandigarh Highway, Lalru 140501, India.
Pradeep K KarlaDepartment of Pharmaceutical Sciences, College of Pharmacy, Howard University, 2300 4th St. N.W., Washington, DC 20059, USA.
Shery JacobDepartment of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman 4184, United Arab Emirates.ORCID 0000-0003-1851-6673
Mansi D AdatiyaLallubhai Motilal College of Pharmacy, Navrangpura, Ahmedabad 380009, India.
Tejas M DhameliyaLallubhai Motilal College of Pharmacy, Navrangpura, Ahmedabad 380009, India.ORCID 0000-0001-5336-9918
Ketan M RanchLallubhai Motilal College of Pharmacy, Navrangpura, Ahmedabad 380009, India.ORCID 0000-0003-3865-8855
Amit K TiwariCenter of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates.ORCID 0000-0002-7427-7155
Ajman University · AEGulf Medical University · AEHoward University · USPanacea Biotec (India) · IN

Funding

Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI Tatiana V.D. Sanses · 2019 to 2026
$37.7M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1RR031975 · NCRR · GEORGETOWN UNIVERSITY · PI VERBALIS, JOSEPH G · 2010 to 2011
$14.6M
NCRR NIH HHS UL1 RR031975NIMHD NIH HHS U54 MD007597
6 · The paper itself

Abstract

Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good biocompatibility, slow degradability and flexible physicochemical modification. The degradation rates of poly(amino acid)s are influenced by the hydrophilicity of the amino acids that make up the polymer. Poly(amino acid)s are extensively used in the formulation of chemotherapeutics to achieve selective delivery for an appropriate duration of time in order to lessen the drug-related side effects and increase the anti-tumor efficacy. This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility. A thorough discussion on anticancer agents incorporated into poly(amino acid) micellar systems that are under clinical evaluation is included.

Indexed as

biopolymersdrug deliverymicellesnanocarrierspolyamidespoly(amino acid)s

Identifiers

PMID34698184
PMCPMC8544418
OpenAlexW3205520228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.