Evidence map›Paper›PMID 34698119›Full record

ArticleCurrent issues in molecular biology2021

Diversification of Ferredoxins across Living Organisms.

Nomfundo Nzuza, Tiara Padayachee, Wanping Chen, Dominik Gront, David R Nelson, Khajamohiddin Syed

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. The human gut microbeApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Article
  4. Insights into the Role of the D-Cluster in [NiFe]-CODH from Rhodospirillum Rubrum.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  5. Analysis of the Setomimycin Biosynthetic Gene Cluster fromInternational journal of molecular sciences · 2024
    Article
  6. Review
  7. Review
  8. Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea.International journal of molecular sciences · 2023
    Article
  9. Review
  10. Contrasting Health Effects ofInternational journal of molecular sciences · 2022
    Article
  11. Article
  12. Structural insights into 3Fe-4S ferredoxins diversity inFrontiers in molecular biosciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nomfundo NzuzaDepartment of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.
Tiara PadayacheeDepartment of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.ORCID 0000-0001-6667-9982
Wanping ChenDepartment of Molecular Microbiology and Genetics, University of Göttingen, 37077 Göttingen, Germany.
Dominik GrontFaculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.ORCID 0000-0002-2260-2083
David R NelsonDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-0583-5421
Khajamohiddin SyedDepartment of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.ORCID 0000-0002-1497-3570

Funding

National Research Foundation, South Africa 114159Polish National Science Centre (NCN) 2018/29/B/ST6/01989University of Zululand C686
6 · The paper itself

Abstract

Ferredoxins, iron-sulfur (Fe-S) cluster proteins, play a key role in oxidoreduction reactions. To date, evolutionary analysis of these proteins across the domains of life have been confined to observing the abundance of Fe-S cluster types (2Fe-2S, 3Fe-4S, 4Fe-4S, 7Fe-8S (3Fe-4s and 4Fe-4S) and 2[4Fe-4S]) and the diversity of ferredoxins within these cluster types was not studied. To address this research gap, here we propose a subtype classification and nomenclature for ferredoxins based on the characteristic spacing between the cysteine amino acids of the Fe-S binding motif as a subtype signature to assess the diversity of ferredoxins across the living organisms. To test this hypothesis, comparative analysis of ferredoxins between bacterial groups,

Indexed as

Genetic VariationArchaeaBacteriaComputational BiologyDatabases, GeneticEukaryotaEvolution, MolecularFerredoxinsPhylogenySpecies SpecificityFerredoxinsArchaeaBacteriadomains of lifeEukaryaevolutionferredoxinsiron-sulfur proteinslateral gene transfer

Identifiers

PMID34698119
PMCPMC8928951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.