Evidence map›Paper›PMID 34698116›Full record

ArticleCurrent issues in molecular biology2021

FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon Receptor-Mediated Transcription in ARPE-19 Cells.

Kwang Won Jeong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kwang Won JeongGachon Research Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 406-799, Korea.ORCID 0000-0003-2258-8354
Gachon University · KR

Funding

National Research Foundation of Korea NRF-2021R1A2C1011132
6 · The paper itself

Abstract

Aryl hydrocarbon receptors (AHRs), a class of ligand-dependent nuclear receptors that regulate cellular responses by inducing the expression of various target genes in response to external signals, are implicated in maintaining retinal tissue homeostasis. Previous studies have shown that the regulation of AHR-induced gene expression requires transcriptional co-regulators. However, it is not yet clear how chromatin remodelers, histone methyltransferases and coactivators interact during AHR-mediated gene expression in human retinal cells. In this study, we reveal that the histone methyltransferase MLL1 and the coactivator FLII are involved in AHR-mediated gene expression in retinal pigment epithelial cells. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly increased the expression of

Indexed as

Gene Expression RegulationTranscriptional ActivationBasic Helix-Loop-Helix ProteinsCell LineChromatin ImmunoprecipitationCytochrome P-450 CYP1A1Epithelial CellsGene Expression ProfilingHistone-Lysine N-MethyltransferaseHumansMicrofilament ProteinsMyeloid-Lymphoid Leukemia ProteinProtein BindingReceptors, Aryl HydrocarbonRetinal Pigment EpitheliumTrans-ActivatorsAHR protein, humanBasic Helix-Loop-Helix ProteinsCytochrome P-450 CYP1A1FLII protein, humanHistone-Lysine N-MethyltransferaseKMT2A protein, humanMicrofilament ProteinsMyeloid-Lymphoid Leukemia ProteinReceptors, Aryl HydrocarbonTrans-Activatorsaryl hydrocarbon receptorBRG1FLIIMLL1retinal pigment epithelial celltranscription

Identifiers

PMID34698116
PMCPMC8929146
OpenAlexW3206977881

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.