Evidence map›Paper›PMID 34698084›Full record

ArticleCurrent issues in molecular biology2021

Synthetic Oligopeptides Mimicking γ-Core Regions of Cysteine-Rich Peptides of

Marina P Slezina, Ekaterina A Istomina, Ekaterina V Kulakovskaya, Tatiana N Abashina, Tatyana I Odintsova

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Antimicrobial Potential of Defensin-DerivedInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Broad-Spectrum Antimicrobial Potential of the γ-Core Motif Peptides ofInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Various Biomimetics, Including Peptides as Antifungals.Biomimetics (Basel, Switzerland) · 2023
    Review
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marina P SlezinaVavilov Institute of General Genetics RAS, 119333 Moscow, Russia.ORCID 0000-0003-1653-5993
Ekaterina A IstominaVavilov Institute of General Genetics RAS, 119333 Moscow, Russia.ORCID 0000-0001-6426-6009
Ekaterina V KulakovskayaFederal Research Center, Pushchino Scientific Center for Biological Research of the Russian Academy of Science, Skryabin Institute of Biochemistry and Physiology of Microorganisms RAS, 142290 Pushchino, Russia.
Tatiana N AbashinaFederal Research Center, Pushchino Scientific Center for Biological Research of the Russian Academy of Science, Skryabin Institute of Biochemistry and Physiology of Microorganisms RAS, 142290 Pushchino, Russia.
Tatyana I OdintsovaVavilov Institute of General Genetics RAS, 119333 Moscow, Russia.ORCID 0000-0002-5563-9755

Funding

Russian Science Foundation 16-16-00032
6 · The paper itself

Abstract

Plant cysteine-rich peptides (CRPs) represent a diverse group of molecules involved in different aspects of plant physiology. Antimicrobial peptides, which directly suppress the growth of pathogens, are regarded as promising templates for the development of next-generation pharmaceuticals and ecologically friendly plant disease control agents. Their oligopeptide fragments are even more promising because of their low production costs. The goal of this work was to explore the antimicrobial activity of nine short peptides derived from the γ-core-containing regions of tomato CRPs against important plant and human pathogens. We discovered antimicrobial activity in peptides derived from the defensin-like peptides, snakins, and MEG, which demonstrates the direct involvement of these CRPs in defense reactions in tomato. The CRP-derived short peptides appeared particularly active against the gram-positive bacterium

Indexed as

Amino Acid SequenceAntimicrobial PeptidesBacteriaChemistry Techniques, SyntheticCysteineDose-Response Relationship, DrugMicrobial Sensitivity TestsModels, MolecularOligopeptidesPlant DiseasesProtein ConformationSolanum lycopersicumSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationStructure-Activity RelationshipYeastsAntimicrobial PeptidesCysteineOligopeptidesantimicrobial peptidescysteine-rich peptideshuman pathogensplant immunityplant pathogensγ-core

Identifiers

PMID34698084
PMCPMC8929047

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.