Evidence map›Paper›PMID 34698059›Full record

ArticleCurrent issues in molecular biology2021

Renadirsen, a Novel 2'OMeRNA/ENA

Kentaro Ito, Hideo Takakusa, Masayo Kakuta, Akira Kanda, Nana Takagi, Hiroyuki Nagase, Nobuaki Watanabe, Daigo Asano, Ryoya Goda, Takeshi Masuda and 7 more

Open access · goldAbstract read
In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Therapeutic approaches for Duchenne muscular dystrophy.Nature reviews. Drug discovery · 2023
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Kentaro ItoSpecialty Medicine Research Laboratories I, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1408710, Japan.
Hideo TakakusaDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1408710, Japan.
Masayo KakutaMedical Information Department, Daiichi Sankyo Co., Ltd., Chuo, Tokyo 1038426, Japan.
Akira KandaSpecialty Medicine Research Laboratories I, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1408710, Japan.
Nana TakagiSafety and Risk Management Department, Daiichi Sankyo Co., Ltd., Chuo, Tokyo 1038426, Japan.
Hiroyuki NagaseSpecialty Medicine Research Laboratories I, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1408710, Japan.
Nobuaki WatanabeDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1408710, Japan.
Daigo AsanoDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1408710, Japan.
Ryoya GodaDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1408710, Japan.
Takeshi MasudaModality Research Laboratories, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1409710, Japan.
Akifumi NakamuraModality Research Laboratories, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1409710, Japan.
Yoshiyuki OnishiModality Research Laboratories, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1409710, Japan.
Toshio OnodaIntellectual Property Department, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1409710, Japan.
Makoto KoizumiModality Research Laboratories, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1409710, Japan.
Yasuhiro TakeshimaDepartment of Pediatrics, Hyogo College of Medicine, Nishinomiya 6638501, Japan.ORCID 0000-0002-6468-7185
Masafumi MatsuoResearch Center for Locomotion Biology, Kobe Gakuin University, Nishi, Kobe 6512180, Japan.
Kiyosumi TakaishiSpecialty Medicine Research Laboratories I, Daiichi Sankyo Co., Ltd., Shinagawa, Tokyo 1408710, Japan.
Daiichi-Sankyo (Japan) · JPHyogo Medical University · JPKobe Gakuin University · JP

Funding

Daiichi Sankyo Co., Ltd.Orphan Disease Treatment Institute Co., Ltd.
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by out-of-frame or nonsense mutation in the dystrophin gene. It begins with a loss of ambulation between 9 and 14 years of age, followed by various other symptoms including cardiac dysfunction. Exon skipping of patients'

Indexed as

Alternative SplicingAnimalsChromatography, LiquidDystrophinMaleMiceMice, Inbred mdxMolecular StructureMuscle, SkeletalMyocardiumOligodeoxyribonucleotidesOligonucleotides, AntisenseOligoribonucleotidesTandem Mass SpectrometryTissue DistributionDystrophinOligodeoxyribonucleotidesOligonucleotides, AntisenseOligoribonucleotides2′-O,4′-C-ethylene-bridged nucleic acid (ENA)antisense oligonucleotidecardiac muscleDuchenne muscular dystrophydystrophinexon skippingrenadirsen sodium

Identifiers

PMID34698059
PMCPMC8928966
OpenAlexW3203079890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.