Evidence map›Paper›PMID 34698017›Full record

ArticleeLife2021

Fascin limits Myosin activity within

Maureen C Lamb, Chathuri P Kaluarachchi, Thiranjeewa I Lansakara, Samuel Q Mellentine, Yiling Lan, Alexei V Tivanski, Tina L Tootle

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Actomyosin contraction in the follicular epithelium provides the major mechanical force for follicle rupture duringProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Finishing the egg.Genetics · 2024
    Article
  5. microPublication biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maureen C LambAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, United States.ORCID 0000-0002-4522-1910
Chathuri P KaluarachchiDepartment of Chemistry, University of Iowa, Iowa City, United States.ORCID 0000-0003-2538-3952
Thiranjeewa I LansakaraDepartment of Chemistry, University of Iowa, Iowa City, United States.
Samuel Q MellentineAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, United States.
Yiling LanDepartment of Chemistry, University of Iowa, Iowa City, United States.
Alexei V TivanskiDepartment of Chemistry, University of Iowa, Iowa City, United States.
Tina L TootleAnatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, United States.ORCID 0000-0002-1515-9538
University of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008629 · NIGMS · UNIVERSITY OF IOWA · PI EBERL, DANIEL F · 1997 to 2021
$4.1M
Prostaglandins control development by coordinating actin cytoskeletal remodelingR01GM116885 · NIGMS · UNIVERSITY OF IOWA · PI TOOTLE, TINA L · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM116885NIGMS NIH HHS T32 GM008629NIH HHS P40 OD018537
6 · The paper itself

Abstract

A key regulator of collective cell migrations, which drive development and cancer metastasis, is substrate stiffness. Increased substrate stiffness promotes migration and is controlled by Myosin. Using

Indexed as

AnimalsCarrier ProteinsCell MovementDrosophila melanogasterMicrofilament ProteinsMyosinsCarrier ProteinsfascinMicrofilament ProteinsMyosinsborder cellscell biologycollective cell migrationdevelopmental biologyD. melanogasterFascinmechanotransductionmyosinstiffness

Identifiers

PMID34698017
PMCPMC8547955
OpenAlexW3208211160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.