ArticleCancer medicine2021
Lymph node status and its impact on the prognosis of left-sided and right-sided colon cancer: A SEER population-based study.
Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Nomogram for preoperative prediction of lymph node metastasis in patients with early submucosal right-sided colon cancer: a dual-center retrospective cohort study.Surgical endoscopy · 2026Article
- Clinical Significance of Lymph Node Count in Colon Cancer Surgery: A Tumour Location-stratified Prognostic Analysis Based on an Integrated Phase-III Randomized Controlled Trial (JCOG2310AS3).Journal of the anus, rectum and colon · 2026Article
- Article
- A prognostic nomogram for predicting recurrence-free survival of stage I-III colon cancer based on immune-infiltrating Treg-related genes.Journal of cancer research and clinical oncology · 2023Article
- Correlations between Demographic, Clinical, and Paraclinical Variables and Outcomes in Patients with KRAS-Mutant or KRAS Wild-Type Metastatic Colorectal Cancer-A Retrospective Study from a Tertiary-Level Center in Romania.Diagnostics (Basel, Switzerland) · 2023Article
- Log odds of positive lymph nodes show better predictive performance on the prognosis of early-onset colorectal cancer.International journal of colorectal disease · 2023Article
- Stage III deficient mismatch repair colon patients get greater benefit from earlier starting oxaliplatin-based chemotherapy regimen.Scientific reports · 2023Article
- Lymph node metastasis in T1-2 colorectal cancer: a population-based study.International journal of colorectal disease · 2023Article
- Article
- Predicting the Risk of Incorrect Inhalation Technique in Patients with Chronic Airway Diseases by a New Predictive Nomogram.Journal of asthma and allergy · 2023Article
- Development and validation of a survival prediction model for 113,239 patients with colon cancer: a retrospective cohort study.Journal of gastrointestinal oncology · 2022Article
- TRIM27 is an adverse prognostic biomarker and associated with immune and molecular profiles in right-sided colon cancer.American journal of cancer research · 2022Article
- Survival Nomogram for Metastasis Colon Cancer Patients Based on SEER Database.Frontiers in genetics · 2022Article
- Lymph node status and its impact on the prognosis of left-sided and right-sided colon cancer: A SEER population-based study.Cancer medicine · 2021Article
- A 3 M Evaluation Protocol for Examining Lymph Nodes in Cancer Patients: Multi-Modal, Multi-Omics, Multi-Stage Approach.Technology in cancer research & treatmentReview
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSome significant differences exist between the outcomes of left- and right-sided colon cancer patients. The presence of nodal metastases is a critical prognostic factor, especially in the absence of distant metastasis. Our research studied the lymph nodes status of left- and right-sided colon cancer patients to determine the influence of this factor on prognosis.
methodsOur data were obtained from the Surveillance, Epidemiology and End Results (SEER) database. We used the chi-square test to analyze the clinicopathological characteristics. The X-tile program was adopted to acquire optimal cutoff points of lymph node index. Kaplan-Meier curves were used to analyze prognosis and multivariate Cox regression models were performed to identify the independent factors associated with survival. Nomograms were built to predict the overall survival of patients, Harrell's C-index and calibration plots were used to validate the nomograms.
resultsThe study included 189,941 patients with colon cancer without metastasis (left 69,885, right 120,056) between 2004 and 2015. There are more patients with adequate examined lymph nodes in right-sided. Lymph node status in patients with right colon cancer has a more significant impact on the risk of death. LODDS (C-index: 0.583; AIC: 6875.4) was used to assess lymph node status. The nomograms showed that lymph node status was the main factor to predict the outcome in right-sided colon patients.
conclusionsThe influence of lymph node status on predicting prognosis is significantly different between patients with left and right colon cancer without metastasis. The tumor site needs to be considered when lymph node status is used to assess the outcome of patients.
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