Evidence map›Paper›PMID 34697907›Full record

ArticleThe journal of pathology. Clinical research2022

Diagnostic and prognostic implications of a three-antibody molecular subtyping algorithm for non-muscle invasive bladder cancer.

Chelsea L Jackson, Lina Chen, Céline Sc Hardy, Kevin Ym Ren, Kash Visram, Vanessa F Bratti, Jeannette Johnstone, Gottfrid Sjödahl, David Robert Siemens, Robert J Gooding and 1 more

Open access · goldAbstract read
In one paragraph

Article in The journal of pathology. Clinical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  8. Review
  9. Review
  10. Immunohistochemical Assays for Bladder Cancer Molecular Subtyping: Optimizing Parsimony and Performance of Lund Taxonomy Classifiers.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Chelsea L JacksonDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.ORCID 0000-0002-6784-5978
Lina ChenDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Céline Sc HardyDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Kevin Ym RenDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Kash VisramDepartment of Urology, Queen's Cancer Research Institute, Queen's University, Kingston, ON, Canada.
Vanessa F BrattiDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Jeannette JohnstoneDepartment of Urology, Queen's Cancer Research Institute, Queen's University, Kingston, ON, Canada.
Gottfrid SjödahlDivision of Urologic Research, Department of Translational Medicine, Lund University, Lund, Sweden.ORCID 0000-0002-7869-0473
David Robert SiemensDepartment of Urology, Queen's Cancer Research Institute, Queen's University, Kingston, ON, Canada.
Robert J GoodingDivision of Cancer Biology and Genetics, Queen's Cancer Research Institute, Queen's University, Kingston, ON, Canada.
David M BermanDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.ORCID 0000-0001-5985-3698
Queen's University · CALund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrinsic molecular subtypes may explain marked variation between bladder cancer patients in prognosis and response to therapy. Complex testing algorithms and little attention to more prevalent, early-stage (non-muscle invasive) bladder cancers (NMIBCs) have hindered implementation of subtyping in clinical practice. Here, using a three-antibody immunohistochemistry (IHC) algorithm, we identify the diagnostic and prognostic associations of well-validated proteomic features of basal and luminal subtypes in NMIBC. By IHC, we divided 481 NMIBCs into basal (GATA3

Indexed as

Urinary Bladder NeoplasmsAlgorithmsBiomarkers, TumorHumansPrognosisProteomicsBiomarkers, Tumorbladder cancerGATA3immunohistochemistryKRT5p16

Identifiers

PMID34697907
PMCPMC8822375
OpenAlexW3209209610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.