ArticleThe clinical respiratory journal2022
Serum tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-17 relate to anxiety and depression risks to some extent in non-small cell lung cancer survivor.
Article in The clinical respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Cancer-related inflammation and depressive symptoms: Systematic review and meta-analysis.Cancer · 2022Pooled it
- Effects of Telerehabilitation Based on Motion Recognition Technology on Exercise Endurance of Patients With Non-Small Cell Lung Cancer After Surgery: Single-Center, Prospective, Open-Label, Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Article
- Factors associated with anxiety in colorectal cancer survivors: a scoping review.Journal of cancer survivorship : research and practice · 2026Article
- Article
- Role of depression-mediated alterations in pro-inflammatory cytokines in carcinogenesis.Frontiers in immunology · 2025Review
- Association of inflammation cytokines with cognitive function in first-episode major depressive disorder.Frontiers in psychiatry · 2024Article
- A systematic review and meta-analysis to evaluate blood levels of interleukin-6 in lung cancer patients.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2023Article
- Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms.Neuropsychiatric disease and treatment · 2023Article
- Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study.Clinical practice and epidemiology in mental health : CP & EMH · 2023Article
- Exploring the impact of ketogenic diet on multiple sclerosis: obesity, anxiety, depression, and the glutamate system.Frontiers in nutrition · 2023Review
- Blood T-helper 17 cells and interleukin-17A correlate with the elevated risk of postpartum depression and anxiety.Journal of clinical laboratory analysis · 2022Article
- Serum tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-17 relate to anxiety and depression risks to some extent in non-small cell lung cancer survivor.The clinical respiratory journal · 2022Article
- Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInflammatory cytokines are proposed as modulators for the pathogenesis of anxiety and depression (anxiety/depression), and anxiety/depression are frequently existed in non-small cell lung cancer (NSCLC) survivors. However, no published study has explored the association of inflammation cytokines with anxiety/depression in NSCLC survivors.
objectivesWe aimed to evaluate serum tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-17 (IL-17) levels, and their correlations with anxiety/depression in NSCLC survivors.
methodsTotally, 217 NSCLC survivors and 200 controls were recruited. Then, inflammatory cytokines in serum samples were detected by enzyme-linked immunosorbent assay (ELISA). Besides, their anxiety/depression status was assessed by Hospital Anxiety and Depression Scale (HADS).
resultsHADS-anxiety score, anxiety rate, anxiety severity, HADS-depression score, depression rate, and depression severity were all increased in NSCLC survivors compared with controls (all P < 0.001). Regarding inflammatory cytokines, TNF-α, IL-1β, and IL-17 levels were higher (all P < 0.01), while IL-6 (P = 0.105) level was of no difference in NSCLC survivors compared with controls. Furthermore, TNF-α, IL-1β, IL-6, and IL-17 were all positively associated with HADS-A score (all P < 0.05), anxiety occurrence (all P < 0.05), HADS-D score (all P < 0.05), and depression occurrence (all P < 0.05) in NSCLC survivors, while the correlation-coefficients were weak. Additionally, multivariate logistic regression analyses disclosed that TNF-α (both P < 0.05) and IL-1β (both P < 0.001) were independently correlated with increased anxiety and depression risks in NSCLC survivors.
conclusionSerum TNF-α, IL-1β, IL-6, and IL-17 are related to increased anxiety and depression risks to some extent in NSCLC survivors.
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