Evidence map›Paper›PMID 34697736›Full record

ArticleDoklady. Biochemistry and biophysics2021

Role of Potassium Ions in Regulation of Calcium-Activated Chloride Channels.

V L Zamoyski, E V Bovina, S O Bachurin, V V Grigoriev

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

V L ZamoyskiInstitute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia. vzam@yandex.ru.
E V BovinaInstitute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
S O BachurinInstitute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
V V GrigorievInstitute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
Institute of Physiologically Active Compounds · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using the patch-clamp method in the whole cell configuration, it was shown that external potassium ions play an important role in the regulation of calcium-activated chloride channels (CaCCs). A clear dependence of the conductivity of the СаССs on the external potassium concentration was shown. The effect of external potassium in the range 0-15 mM on the conductivity of chloride channels was significantly greater than the effect it had on other ionic currents (sodium or potassium). There is reason to believe that these changes in the conductivity of CaCCs may contribute to the development of pathophysiological processes such as hypokalemia or hyperkalemia.

Indexed as

Chloride ChannelsPotassiumAnimalsCalciumHumansPatch-Clamp TechniquesCalciumChloride ChannelsPotassiumcalcium-activated chloride channels (CaCCs)patch-clamp methodpotassium ionsPurkinje cells of the rat cerebellum

Identifiers

PMID34697736
OpenAlexW3211306490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.