ArticleCommunications biology2021
Multi-omics approaches explain the growth-promoting effect of the apocarotenoid growth regulator zaxinone in rice.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Genotype-Specific Biochemical Responses of Apple Trees to Repeated Drought-Rehydration Cycles.Plants (Basel, Switzerland) · 2026Article
- Zaxinone mimics boost growth and productivity of wheat under normal and low-nutrient regimes.BMC plant biology · 2026Article
- Regulation of apocarotenoids for quality improvement and biofortification of horticultural crops.Journal of advanced research · 2026Review
- Analyzing Plant Low-Molecular-Weight Polar Metabolites: A GC-MS Approach.Plants (Basel, Switzerland) · 2026Review
- Gas Chromatography-Mass Spectrometry (GC-MS) in the Plant Metabolomics Toolbox: GC-MS in Multi-Platform Metabolomics and Integrated Multi-Omics Research.International journal of molecular sciences · 2026Review
- Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14.Nature communications · 2025Article
- Disruption of the karrikin receptor DWARF 14 LIKE (D14L) gene leads to distinct effects on root and shoot growth, and reprogramming of central metabolism in rice.Journal of experimental botany · 2025Article
- Root remodeling mechanisms and salt tolerance trade-offs: The roles of HKT1, TMAC2, and TIP2;2 in Arabidopsis.PLoS genetics · 2025Article
- In vivo dynamics of indole- and phenol-derived plant hormones: Long-term, continuous, and minimally invasive phytohormone sensor.Science advances · 2025Article
- Zaxinone Synthase overexpression modulates rice physiology and metabolism, enhancing nutrient uptake, growth and productivity.Plant, cell & environment · 2025Article
- Development of a Rapid and Efficient Protocol for Seed Germination and Seedling Establishment ofBio-protocol · 2025Article
- Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3.Frontiers in plant science · 2025Article
- Does zaxinone counteract strigolactones in shaping rice architecture?Plant signaling & behavior · 2023Article
- Disruption of the riceProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Zaxinone mimics (MiZax) efficiently promote growth and production of potato and strawberry plants under desert climate conditions.Scientific reports · 2023Article
- New Series of Zaxinone Mimics (MiZax) for Fundamental and Applied Research.Biomolecules · 2023Article
- A Fast and Cost-Effective Genotyping Method for CRISPR-Cas9-Generated Mutant Rice Lines.Plants (Basel, Switzerland) · 2023Article
- ZAXINONE SYNTHASE 2 regulates growth and arbuscular mycorrhizal symbiosis in rice.Plant physiology · 2023Article
- Carotenoid-derived bioactive metabolites shape plant root architecture to adapt to the rhizospheric environments.Frontiers in plant science · 2022Review
- Evaluation of the Biostimulant Activity of Zaxinone Mimics (MiZax) in Crop Plants.Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The apocarotenoid zaxinone promotes growth and suppresses strigolactone biosynthesis in rice. To shed light on the mechanisms underlying its growth-promoting effect, we employed a combined omics approach integrating transcriptomics and metabolomics analysis of rice seedlings treated with zaxinone, and determined the resulting changes at the cellular and hormonal levels. Metabolites as well as transcripts analysis demonstrate that zaxinone application increased sugar content and triggered glycolysis, the tricarboxylic acid cycle and other sugar-related metabolic processes in rice roots. In addition, zaxinone treatment led to an increased root starch content and induced glycosylation of cytokinins. The transcriptomic, metabolic and hormonal changes were accompanied by striking alterations of roots at cellular level, which showed an increase in apex length, diameter, and the number of cells and cortex cell layers. Remarkably, zaxinone did not affect the metabolism of roots in a strigolactone deficient mutant, suggesting an essential role of strigolactone in the zaxinone growth-promoting activity. Taken together, our results unravel zaxinone as a global regulator of the transcriptome and metabolome, as well as of hormonal and cellular composition of rice roots. Moreover, they suggest that zaxinone promotes rice growth most likely by increasing sugar uptake and metabolism, and reinforce the potential of this compound in increasing rice performance.
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