ArticleScientific reports2021
Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 8 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed, 8 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Effectiveness of non-pharmacological interventions for fatigue in adults with long-term conditions: a synopsis of the EIFFEL mixed-methods evidence synthesis.Health technology assessment (Winchester, England) · 2026Pooled it
- Measurement of fatigue in sickle cell disease: a systematic review of fatigue measures.Orphanet journal of rare diseases · 2025Pooled it
- Residual Fatigue in Unipolar and Bipolar Depression: A Systematic Review.Neuropsychopharmacology reports · 2025Pooled it
- Comparative study for fatigue prevalence in subjects with diseases: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials.Journal of translational medicine · 2024Pooled it
- Effectiveness of physical activity interventions on reducing perceived fatigue among adults with chronic conditions: a systematic review and meta-analysis of randomised controlled trials.Scientific reports · 2023Pooled it
- Prevalence of cancer-related fatigue based on severity: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- The demographic features of fatigue in the general population worldwide: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Transdiagnostic cognitive behavioral therapy for severe and persistent fatigue - a feasibility study in primary care.BMC primary care · 2026Trial
- The Effect of Internet-Based Cognitive Behavioral Therapy (I-CBT) for Severe Fatigue in Adolescents with Immune Dysregulation Disorders: Preliminary Findings using a Multiple Single-Case Experimental Design.Journal of clinical psychology in medical settings · 2026Trial
- Social Isolation and Daily Steps Are Associated With Fatigue in Older Women With Cardiovascular Disease: A Secondary Analysis of the MindMoves Trial.Journal of aging and physical activity · 2026Trial
- Trial
- Blended versus face-to-face cognitive behavioural therapy for severe fatigue in patients with multiple sclerosis: A non-inferiority RCT.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Trial
- Narratives of recovery from persistent fatigue: a stepwise learning process.Scandinavian journal of primary health care · 2026Article
- Fatigue Among Adults Age 18 and Older: United States, 2024.National health statistics reports · 2026Article
- Resting state brain connectivity of pain and fatigue is affected by performance of a fatiguing attention task in patients with chronic pain.Neuroimage. Reports · 2026Article
- Fatigue: assess and address it.Journal of patient-reported outcomes · 2026Article
- Determinants of kinesiophobia in patients with hidradenitis suppurativa: the role of pain, fatigue, physical activity and depression.BMC psychology · 2026Article
- Exploring Core Symptoms and Symptom Clusters Among Older Adults with Hypertension-Diabetes Comorbidity: A Network Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Unravelling the diversity of pacing behaviours in adults with chronic conditions: a cross-sectional study.BMJ open · 2026Observational
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) To evaluate the prevalence of severe and chronic fatigue in subjects with and without chronic disease; (2) to assess to which extent multi-morbidity contributes to severe and chronic fatigue; and (3) to identify predisposing and associated factors for severe and chronic fatigue and whether these are disease-specific, trans-diagnostic, or generic. The Dutch Lifelines cohort was used, including 78,363 subjects with (n = 31,039, 53 ± 12 years, 33% male) and without (n = 47,324, 48 ± 12 years, 46% male) ≥ 1 of 23 chronic diseases. Fatigue was assessed with the Checklist Individual Strength-Fatigue. Compared to participants without a chronic disease, a higher proportion of participants with ≥ 1 chronic disease were severely (23% versus 15%, p < 0.001) and chronically (17% versus 10%, p < 0.001) fatigued. The odds of having severe fatigue (OR [95% CI]) increased from 1.6 [1.5-1.7] with one chronic disease to 5.5 [4.5-6.7] with four chronic diseases; for chronic fatigue from 1.5 [1.5-1.6] to 4.9 [3.9-6.1]. Multiple trans-diagnostic predisposing and associated factors of fatigue were found, explaining 26% of variance in fatigue in chronic disease. Severe and chronic fatigue are highly prevalent in chronic diseases. Multi-morbidity increases the odds of having severe and chronic fatigue. Several trans-diagnostic factors were associated with fatigue, providing a rationale for a trans-diagnostic approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.