ArticleScientific reports2021
Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality.GeroScience · 2025Pooled it
- Imbalanced sleep increases mortality risk by 14-34%: a meta-analysis.GeroScience · 2025Pooled it
- Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis.GeroScience · 2025Pooled it
- Cerebral small vessel disease pathology in COVID-19 patients: A systematic review.Ageing research reviews · 2023Pooled it
- Unveiling Functional-Metabolic Synergy in the Healthy Brain: Multivariate Integration of Dynamic [Human brain mapping · 2026Article
- An NMR-Based Protocol for Profiling the Endo- and Exo-Metabolomes in AβMetabolites · 2026Article
- METTL3-mediated mTranslational psychiatry · 2026Article
- Sleep and Cognitive Dysfunction in Subarachnoid Hemorrhage: A Scoping Review.Journal of clinical medicine · 2026Review
- Transcranial near-infrared therapy restores synaptic resilience by reshaping signaling landscapes in sleep-deprived tauopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Chronotype in alpha-tACS: Preliminary evidence hints at sleep quality modulation of aftereffects in evening types in the morning.Neurobiology of sleep and circadian rhythms · 2025Article
- Difficulty in Attention Switching and Its Neural Basis in Problematic Smartphone Use.Brain sciences · 2025Article
- Unlocking Mysteries: Exploring the Dynamic Interplay Among Sleep, the Immune System, and Curcumin in Contemporary Research.Sleep science (Sao Paulo, Brazil) · 2025Review
- Assessment of Intravoxel Incoherent Motion Diffusion-Weighted Imaging in Insomnia.Brain and behavior · 2025Article
- Effects of selective sleep deprivation on the hemodynamics of healthy individuals: a randomized trial.Journal of thoracic disease · 2025Article
- Transcranial near infrared therapy reprograms metabolism to rescue sleep and place cell functionality.iScience · 2025Article
- Fear/Anxiety and Sleep Deprivation Combine to Predict Courage.Behavioral sciences (Basel, Switzerland) · 2025Article
- Subjective and Objective Cancer-Related Cognitive Impairments Among Systemic and Radiation Therapy-Naïve Female Cancer Patients.Cancer medicine · 2025Article
- Sleep deprivation impairs neurovascular coupling and cerebral vasomotor reactivity.Scientific reports · 2025Article
- Variations of autonomic arousal mediate the reportability of mind blanking occurrences.Scientific reports · 2025Article
- An fNIRS-based investigation of cerebral hemodynamic responses during verbal fluency task and n-back task in individuals with mild cognitive impairment.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
Sleep deprivation (SD) is a common condition and an important health concern. In addition to metabolic and cardiovascular risks, SD associates with decreases in cognitive performance. Neurovascular coupling (NVC, "functional hyperemia") is a critical homeostatic mechanism, which maintains adequate blood supply to the brain during periods of intensive neuronal activity. To determine whether SD alters NVC responses and cognitive performance, cognitive and hemodynamic NVC assessments were conducted prior to and 24 h post-SD in healthy young male individuals (n = 10, 27 ± 3 years old). Cognition was evaluated with a battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Hemodynamic components of NVC were measured by transcranial Doppler sonography (TCD) during cognitive stimulation, dynamic retinal vessel analysis (DVA) during flicker light stimulation, and functional near infrared spectroscopy (fNIRS) during finger tapping motor task. Cognitive assessments revealed impairments in reaction time and sustained attention after 24 h of SD. Functional NIRS analysis revealed that SD significantly altered hemodynamic responses in the prefrontal cortex and somatosensory cortex during a motor task. NVC-related vascular responses measured by DVA and TCD did not change significantly. Interestingly, TCD detected decreased task-associated cerebral blood flow (CBF) in the right middle cerebral artery in sleep deprived participants. Our results demonstrate that 24 h of SD lead to impairments in cognitive performance together with altered CBF and hemodynamic components of cortical NVC responses.
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