Evidence map›Paper›PMID 34697322›Full record

Observational studyScientific reports2021

Treatment for COVID-19-a cohort study from Northern Italy.

Lorenzo Guglielmetti, Daniela Aschieri, Irina Kontsevaya, Francesco Calabrese, Alessandra Donisi, Alberto Faggi, Patrizia Ferrante, Elisa Fronti, Laura Gerna, Maria Cristina Leoni and 9 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lorenzo GuglielmettiSorbonne Université, INSERM, U1135, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, équipe 13, Paris, France. lorenzo.guglielmetti@aphp.fr.
Daniela AschieriCardiology Unit, Castel San Giovanni Hospital, Piacenza, Italy.
Irina KontsevayaResearch Center Borstel, Borstel, Germany.
Francesco CalabreseInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Alessandra DonisiMigration Health Unit, Primary Health Care Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Alberto FaggiInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Patrizia FerranteInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Elisa FrontiInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Laura GernaInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Maria Cristina LeoniInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Franco PaolilloInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Giovanna RattiInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Alessandro RuggieriInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Daria SacchiniInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Marta ScottiInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Caterina ValdattaInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Marco StabilePlastic Surgery Unit, Castel San Giovanni Hospital, Piacenza, Italy.
Gloria TalianiInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Mauro CodeluppiInfectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multicentre, retrospective cohort study with multivariable Cox proportional-hazards modelling and survival-time inverse-probability-weighting, evaluating the impact of different treatments on survival of proven COVID-19 patients admitted to two Hospitals in the province of Piacenza, Italy. Use of tocilizumab and of high doses of low molecular weight heparin, but not of antivirals (either alone or in combination), azithromycin, and any corticosteroid, was independently associated with lower mortality. Our results support further clinical evaluation of high doses of low molecular weight heparin and tocilizumab as COVID-19 therapeutics.

Indexed as

COVID-19 Drug TreatmentAdrenal Cortex HormonesAgedAntibodies, Monoclonal, HumanizedAntiviral AgentsAzithromycinCOVID-19FemaleHeparinHospitalizationHospital MortalityHumansItalyMaleMiddle AgedPatient AdmissionAdrenal Cortex HormonesAntibodies, Monoclonal, HumanizedAntiviral AgentsAzithromycinHeparintocilizumab

Identifiers

PMID34697322
PMCPMC8545945

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.