Evidence map›Paper›PMID 34697149›Full record

ArticleIn vivo (Athens, Greece)

Curcumin Derivative MTH-3 Regulates Palmitate-induced Insulin Resistance in Mouse Myoblast C

Yu-Jen Chiu, Yu-Hsiang Lo, Jai-Sing Yang, Sheng-Chu Kuo, Shih-Chang Tsai

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yu-Jen ChiuDivision of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
Yu-Hsiang LoDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
Jai-Sing YangDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.
Sheng-Chu KuoChinese Medicinal Research and Development Center, China Medical University Hospital, School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
Shih-Chang TsaiDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.; sctsai@mail.cmu.edu.tw.
China Medical University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAt present, there are no effective drugs for the treatment of insulin resistance. MTH-3, a curcumin derivative, exerts potent anti-cancer effects. The aim of the present study was to explore whether MTH-3 is capable of regulating palmitic acid (PA)-induced insulin resistance in C MATERIALS AND

methodsCell viability was examined using the MTT assay. C

resultsTreatment of cells with up to 500 μM PA for 24 h or with 5 or 10 μM MTH-3 had no effect on cell viability. PA induced production of oil droplets in C

conclusionMTH-3 may become an efficient drug for the treatment of insulin resistance and associated diseases.

Indexed as

CurcuminInsulin ResistanceAnimalsCell LineInsulinMiceMyoblastsPalmitatesCurcuminInsulinPalmitatesCurcumin derivativeinsulin resistancemouse myoblast cellsMTH-3palmitic acid

Identifiers

PMID34697149
PMCPMC8627776
OpenAlexW3210677493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.