Evidence map›Paper›PMID 34697147›Full record

ArticleIn vivo (Athens, Greece)

Detection of Cells Displaying High Expression of CLIC4 in Tumor Tissue of Patients With Colorectal Cancer.

Reo Yokoyama, Atsuhito Kubota, Hiroyuki Kojima, Takuji Tanaka, Michihiro Mutoh, Masaru Terasaki

Open access · diamondAbstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Chloride intracellular channels in oncology as potential novel biomarkers and personalized therapy targets: a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Reo YokoyamaSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan.
Atsuhito KubotaSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan.
Hiroyuki KojimaSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan.
Takuji TanakaDepartment of Diagnostic Pathology and Research Center of Diagnostic Pathology, Gifu Municipal Hospital, Gifu, Japan.
Michihiro MutohDepartment of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Masaru TerasakiSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan; terasaki@hoku-iryo-u.ac.jp.
Health Sciences University of Hokkaido · JPGifu Municipal Hospital · JPKyoto Prefectural University of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimChloride intracellular channel 4 (CLIC4) is associated with the progression of colorectal cancer (CRC). However, quantitative differences in CLIC4 expression in epithelial and stromal cells of normal mucosal tissue (NT), cancer adjacent to normal colorectal mucosal tissue (NAT), and CRC tissue remain unclear. MATERIALS AND

methodsWe investigated the number of CLIC4 high-expressing (CLIC4

resultsThe number of CLIC4

conclusionThe number of CLIC4

Indexed as

CarcinogenesisColorectal NeoplasmsCell Line, TumorChloride ChannelsHumansChloride ChannelsCLIC4 protein, humanChloride intracellular channel 4colon cancermalignant cellpathological stagestromal cell

Identifiers

PMID34697147
PMCPMC8627758
OpenAlexW3208794678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.