Evidence map›Paper›PMID 34697094›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

"Tripartite Synapses" in Taste Buds: A Role for Type I Glial-like Taste Cells.

Yuryanni A Rodriguez, Jennifer K Roebber, Gennady Dvoryanchikov, Vivien Makhoul, Stephen D Roper, Nirupa Chaudhari

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Blood biomarkers for the prediction of idiopathic taste dysfunction: a case-control study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Article
  3. Noncanonical Taste Transduction of Sugars Elicits Responses in a Dedicated Subset of Gustatory Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Review
  5. Taste dysfunction in Long COVID.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. The enigma of type III taste bud cells.The Journal of physiology · 2025
    Article
  8. The P2YPurinergic signalling · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Bitter taste receptors.Chemical senses · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. METTL3-mediated mInternational journal of oral science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuryanni A RodriguezDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136.
Jennifer K RoebberGraduate Program in Neurosciences, University of Miami Miller School of Medicine, Miami, Florida 33136.
Gennady DvoryanchikovDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136.
Vivien MakhoulDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136.
Stephen D RoperDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136.ORCID 0000-0001-6049-8320
Nirupa ChaudhariDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136 NChaudhari@med.miami.edu.ORCID 0000-0002-3883-5893
University of Miami · US

Funding

SIGNALING IN TASTE CELLSR01DC006308 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHAUDHARI, NIRUPA · 2005 to 2020
$4.9M
Research Supplement to Promote Diversity in Health-Related Research-Functions of gustatory afferent neuron types.R01DC018733 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHAUDHARI, NIRUPA, ROPER, STEPHEN D. · 2020 to 2025
$3.3M
Mapping gustatory neuron types.R01DC017303 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHAUDHARI, NIRUPA · 2019 to 2023
$2.3M
NIDCD NIH HHS R01 DC006308NIDCD NIH HHS R01 DC017303NIDCD NIH HHS R01 DC018733
6 · The paper itself

Abstract

In mammalian taste buds, Type I cells comprise half of all cells. These are termed "glial-like" based on morphologic and molecular features, but there are limited studies describing their function. We tested whether Type I cells sense chemosensory activation of adjacent chemosensory (i.e., Types II and III) taste bud cells, similar to synaptic glia. Using

Indexed as

AnimalsFemaleMiceSynapsesSynaptic TransmissionTasteTaste Budsgliaparacrinepurinoceptorsensorysynaptic transmission

Identifiers

PMID34697094
PMCPMC8638694
OpenAlexW3210233996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.