ArticleeNeuro
Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Population geometries in frontal cortex coordinate value-based decisions.bioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- Thalamocortical bursts encode reward contingencies and drive associative learning.Nature communications · 2026Article
- Low-dimensional population dynamics in the brainstem gate REM sleep.Nature neuroscience · 2026Article
- Neural population dynamics of direct electrical stimulation of neocortex.Cell reports · 2026Article
- Magnetic resonance identification tags for ultra-flexible electrodes.Nature communications · 2026Article
- Article
- LFP-LOC: an LFP power-based method for validating the anatomical placement of high-density neural probes in rodents.Frontiers in neuroscience · 2026Article
- Brain-wide analysis reveals movement encoding structured across and within brain areas.Nature neuroscience · 2026Article
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
- Mapping neural subspace dynamics onto the structure of the mouse descending motor system.bioRxiv : the preprint server for biology · 2025Article
- Article
- A pipeline for mouse brain registration to an atlas after in vivo neurophysiological recordings.Anatomical science international · 2025Article
- Monolithic three-dimensional neural probes from deterministic rolling of soft electronics.Nature electronics · 2025Article
- Striatal pathways oppositely shift cortical activity along the decision axis.bioRxiv : the preprint server for biology · 2025Article
- Gene therapies alleviate absence epilepsy associated withbioRxiv : the preprint server for biology · 2025Article
- Article
- Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans.Nature communications · 2025Article
- A brainstem map of orofacial rhythms.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Commented on by
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Recently developed probes for extracellular electrophysiological recordings have large numbers of electrodes on long linear shanks. Linear electrode arrays, such as Neuropixels probes, have hundreds of recording electrodes distributed over linear shanks that span several millimeters. Because of the length of the probes, linear probe recordings in rodents usually cover multiple brain areas. Typical studies collate recordings across several recording sessions and animals. Neurons recorded in different sessions and animals thus have to be aligned to each other and to a standardized brain coordinate system. Here, we evaluate two typical workflows for localization of individual electrodes in standardized coordinates. These workflows rely on imaging brains with fluorescent probe tracks and warping 3D image stacks to standardized brain atlases. One workflow is based on tissue clearing and selective plane illumination microscopy (SPIM), whereas the other workflow is based on serial block-face two-photon (SBF2P) microscopy. In both cases electrophysiological features are then used to anchor particular electrodes along the reconstructed tracks to specific locations in the brain atlas and therefore to specific brain structures. We performed groundtruth experiments, in which motor cortex outputs are labeled with ChR2 and a fluorescence protein. Light-evoked electrical activity and fluorescence can be independently localized. Recordings from brain regions targeted by the motor cortex reveal better than 0.1-mm accuracy for electrode localization, independent of workflow used.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.